The Toxicity and Absorption of 2-Sulfanilamidopyridine and Its Soluble Sodium Salt

Synthesis, Characterization and Antimicrobial Screening of Benzene Sulfonamide, 4-Amino-N- (5-Methyl-3-Isoxazolyl) Monosilver Salt and Related Compounds

“…The various silver sulfonamide complexes were prepared by reacting silver nitrate with sodium salts of sulfonamides [6][7][8][9] .…”

“…Studies on their metal chelates could have much physiological and pharmacological relevance, because the metal chelates of sulfa drugs have been found to be more bacteriostatic than the drugs themselves 5 . Besides, silver has been used in medicine for many years 6 . In antibacterial therapy, microorganisms show resistance to the existing antibacterial agents.…”

Pharmacology of the Sulphanilamide Group

“…M & B 693 is absorbed and excreted more slowly than sulphanilamide in animals (Marshall, Bratton, and Litchfield, 1938). It reaches the cerebrospinal fluid, but, more slowly than sulphanilamide (Baines and Wien, 1939; unpublished observations from this laboratory).…”

“…So far as can be ascertained at present the drug does not undergo any other change in the body; for 90 per cent. of the total sulphanilamide given to mice can be found in the urine either as sulphanilamide or as acetyl sulphanilamide (Marshall, 1939). In the urine the acetyl form accounts for over 50 per cent.…”

“…In animals it is mostly the acute toxic symptoms which have been described; these consist entirely of nervous symptoms-a paralysis with incoordinate movements in the case of sulphanilamide, and in the case of M & B 693 and the sulphones a state of hyperexcitability with convulsions (Marshall, Bratton, and Litchfield, 1938). In patients, on the other hand, these acute toxic symptoms have not been observed, the doses of the drugs being proportionally very much smaller.…”