The Toxicity of 3-(Acetonylbenzyl)-4-Hydroxycoumarin (Warfarin) to Laboratory Animals*

Hagan, Ernest C.; Radomski, Jack L.

doi:10.1002/jps.3030420620

Cited by 26 publications

(13 citation statements)

References 5 publications

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“…Again no experimental details were given. Hagan & Radomski (1953) partly support Reiff & Wiesmann (1951) in that the figure they arrived at for the LD50 of warfarin (sodium salt) for male albino rats was 58 + 18 mg./kg. ; but they also found the LD50 to females to be 323 + 70 mg./kg.…”

Section: Toxicity To Non-rodentssupporting

confidence: 56%

“…According to the findings of the Hazleton Laboratories-reported by Gates Even assuming the upper figure, this is still about one-tenth of the average lethal dose of warfarin (200-300 mg./kg.) found by Hagan & Radomski (1953) for dogs. On the other hand, Papworth (1958) states that U.S.…”

Section: Toxicity To Non-rodentsmentioning

confidence: 80%

“…and for rabbits, between 100 and 150 mg./kg. Hagan & Radomski (1953) found the LD50 of warfarin for rabbits to 144…”

Section: Toxicity To Non-rodentsmentioning

confidence: 99%

“…Diphacinone is, however, twenty times as toxic to the rabbit if the warfarin figure of 800 mg./kg. found by Hagan & Radomski (1953) for that animal is used for comparison. According to the findings of the Hazleton Laboratories-reported by Gates Even assuming the upper figure, this is still about one-tenth of the average lethal dose of warfarin (200-300 mg./kg.)…”

Section: Toxicity To Non-rodentsmentioning

confidence: 99%

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The comparative rodenticidal efficiency of five anti-coagulants

Bentley

Larthe

1959

J. Hyg.

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1. Results are presented of palatability tests and chronic toxicity tests with five anti-coagulant rodenticides at a variety of concentrations against wild Rattus norvegicus, R. rattus and Mus musculus. These results are compared with similar data for warfarin. Estimates are also given of the acute oral toxicity of two of the five, fumarin and diphacinone, to white rats.2. The toxicity of the compounds vis-à-vis warfarin is examined from the standpoint of the risks to domestic animals involved in their use as rodenticides.3. Coumachlor, 2-isovaleryl-1, 3-indandione and 2-naphthyl-1, 3-indandione are considered to be less effective than warfarin against R. norvegicus. Their effectiveness against R. rattus remains to be demonstrated.4. Fumarin appears to be about as good as warfarin against R. norvegicus and R. rattus at similar concentrations. It appears to be slightly less effective against M. musculus.5. Diphacinone at 0·0025% is regarded as a good alternative to 0·005% warfarin against R. norvegicus. At 0·0125% it is probably more effective against R. rattus than is 0·025% warfarin. The two poisons are about equally effective at this strength against M. musculus, but diphacinone is probably slightly more dangerous for domestic animals.6. The results of a small number of field trials with fumarin and diphacinone are briefly summarized.So many of our colleagues and others have helped at some stage or other of our investigations that it would be tedious to mention them all by name. We must, however, single out for our special thanks Mrs M. Rowe and Miss E. Taylor who carried out a large number of the laboratory tests, Mr A. Taylor on whose chemical experience and facilities we have freely drawn and Mr C. H. B. Worrall, Miss B. Jones, Mr S. R. Surtees and Mr J. H. Cuthbert (Department of Agriculture for Scotland) who carried out the field trials.

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Section: Toxicity To Non-rodentssupporting

confidence: 56%

Section: Toxicity To Non-rodentsmentioning

confidence: 80%

“…and for rabbits, between 100 and 150 mg./kg. Hagan & Radomski (1953) found the LD50 of warfarin for rabbits to 144…”

Section: Toxicity To Non-rodentsmentioning

confidence: 99%

Section: Toxicity To Non-rodentsmentioning

confidence: 99%

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The comparative rodenticidal efficiency of five anti-coagulants

Bentley

Larthe

1959

J. Hyg.

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“…Anticoagulants, principally warfarin, are used extensively in rodent control, but their use in controlling rabbits has been limited by their low toxicity and the need to provide repeated doses (Hagan & Radomski 1953, Clark 1975. Domestic rabbits are however, extremely susceptible to a single dose of brodifacoum, one of a new series of halogenated anticoagulants (Dubock 1978).…”

Section: Introductionmentioning

confidence: 99%