The toxicity of dimethyl sulphoxide (DMSO) for the dog, pig, rat and rabbit

Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer

“…GSI was dissolved in DMSO, which was also used in control cases. Although DMSO shows cytotoxicity in animal models, the amount (50 μL/animal) used in this study did not affect survival rates 42 .…”

Efficacy of 2-APB (2-Aminoethyldiphenylborate) in Rescuing Neurons After Soman-Induced Brain Injury

“…Early toxicological studies indicate that rats can tolerate chronic administration of 9 ml/kg/day DMSO before showing any signs of toxicity (Noel et al, 1975). There have been numerous reports of free radical scavenging and other beneficial effects of DMSO, in rats, at dosages between 1.0 and 6.0 ml/kg (e.g., Wang et al, 2000;Lind et al, 2000;Chang et al, 2001;Nakamuta et al, 2001).…”

Oxygen Radicals Promote ICAM-1 Expression and Microcirculatory Disturbances in Experimental Acute Pancreatitis

“…In most studies, the role of oxygen radicals has been evaluated indirectly by application of oxygen radical scavengers [31][32][33]. DMSO is a potent membrane-permeable W OH scavenger with low toxicity [34,35]. DMSO has been safely applied in humans at the concentration employed in our experiments (50% solution) [36].…”