The toxicity of perfluorodecanoic acid is mainly manifested as a deflected immune function

Li, Keming; Zhao, Qian; Ziyan, Fan; Jia, Shouyin; Liu, Qing; Liu, Fengyan; Liu, Shili

doi:10.1007/s11033-022-07272-w

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…Cytotoxic behavior and nonbiodegradability were observed in some of the compounds, which may raise questions about the greenness of the DESs. Dodecanol, cresols, 4-cyanophenol, para -chlorophenol, Triton X-100, Triton X-, TOPO, and perfluorodecanoic acid, as well as quarternary amines, are associated with toxic traits. − Constituents such as para -chlorophenol, perfluorodecanoic acid, and ibuprofen also show bioaccumulative tendencies. − Moreover, the functionality of DESs depends upon the interactions among the components, and they can show properties that discrete components do not possess. There are reports on hydrophilic DESs where the synthesized DES shows higher toxicity than the individual components. , Hayyan et al accessed the toxicity effect of choline chloride-centered DESs on mice cells and, on the basis of the IC 50 and LC 50 values, concluded that the assembled DESs were more toxic than the individual components .…”

Section: Future Scope and Challengesmentioning

confidence: 99%

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

et al. 2023

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Deep eutectic solvents (DESs) are multicomponent designer solvents that exist as stable liquids over a wide range of temperatures. Over the last two decades, research has been dedicated to developing noncytotoxic, biodegradable, and biocompatible DESs to replace commercially available toxic organic solvents. However, most of the DESs formulated until now are hydrophilic and disintegrate via dissolution on coming in contact with the aqueous phase. To expand the repertoire of DESs as green solvents, hydrophobic DESs (HDESs) were prepared as an alternative. The hydrophobicity is a consequence of the constituents and can be modified according to the nature of the application. Due to their immiscibility, HDESs induce phase segregation in an aqueous solution and thus can be utilized as an extracting medium for a multitude of compounds. Here, we review literature reporting the usage of HDESs for the extraction of various organic compounds and metal ions from aqueous solutions and absorption of gases like CO 2 . We also discuss the techniques currently employed in the extraction processes. We have delineated the limitations that might reduce the applicability of these solvents and also discussed examples of how DESs behave as reaction media. Our review presents the possibility of HDESs being used as substitutes for conventional organic solvents.

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Section: Future Scope and Challengesmentioning

confidence: 99%

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

et al. 2023

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“…Perfluorodecanoic acid (PFDA), a noxious and enduring organic pollutant, is extensively utilized in various food-related domains, including food packaging and cookware [1,2]. Due to its widespread use, this chemical is frequently detected in many animals and in human populations worldwide, and concerns have been raised about its impact on the environment, food safety, and human health [3,4].…”

Section: Introductionmentioning

confidence: 99%

(−)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice

Xu,

Zhong,

Wang

et al. 2023

Molecules

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Perfluorodecanoic acid (PFDA), an enduring and harmful organic pollutant, is widely employed in diverse food-related sectors. Our previous studies have provided evidence that PFDA has the potential to facilitate obesity and hepatic fat accumulation induced by high-fat diet (HFD) intake. Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, has been suggested to possess potential preventive effects against metabolic abnormalities and fatty liver. The purpose of this research was to investigate the effects of EGCG on PFDA-exacerbated adiposity and hepatic lipid accumulation in HFD-fed mice. The results showed that EGCG reduced body weight gain; tissue and organ weights; blood glucose, serum insulin, HOMA-IR, leptin, and lipid parameters; serum inflammatory cytokines (IL−1β, IL−18, IL−6, and TNF−α); and hepatic lipid accumulation in PFDA-exposed mice fed an HFD. Further work showed that EGCG improved liver function and glucose homeostasis in mice fed an HFD and co-exposed to PFDA. The elevated hepatic mRNA levels of SREBP-1 and associated lipogenic genes, NLRP3, and caspase−1 in PFDA-exposed mice fed an HFD were significantly decreased by EGCG. Our work provides evidence for the potential anti-obesity effect of EGCG on co-exposure to HFD and PFDA and may call for further research on the bioactivity of EGCG to attenuate the endocrine disruption effects of long-term exposure to pollutants.

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Chemical toxicity of per- and poly-fluorinated alkyl substances (PFAS)

Christian

2024

Encyclopedia of Toxicology

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The toxicity of perfluorodecanoic acid is mainly manifested as a deflected immune function

Cited by 6 publications

References 54 publications

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

(−)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice

Chemical toxicity of per- and poly-fluorinated alkyl substances (PFAS)

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