2020
DOI: 10.1016/j.fct.2019.111069
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The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects

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Cited by 66 publications
(40 citation statements)
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“…Because the first ILs showed a clear green character, there was the assumption, if not the hope, that this could be extended to all the ILs (Petkovic et al 2011 ; Earle and Seddon 2000 ). However, in the 2000s, several biological studies highlighted a moderate-to-high toxicity of ILs towards several micro-organisms, plants, cell lines, and potentially humans (Bernot et al 2005 ; Pretti et al 2006 ; Pham et al 2008 ; Studzińska and Buszewski 2009 ; Matzke et al 2009 ; Li et al 2009 ; Coleman and Gathergood 2010 ; Frade and Afonso 2010 ; Costa et al 2017 ; Bubalo et al 2017 ; Thamke et al 2019 ; Pawłowska et al 2019 ; Leitch et al 2020a ; Leitch et al 2020b ). For example, ILs based on amino acids (Benedetto et al 2014a ), which were supposed to be more bio-friendly, turned out to have higher toxicity level than their common counterparts (Egorova et al 2015 ).…”
Section: Introductionmentioning
confidence: 99%
“…Because the first ILs showed a clear green character, there was the assumption, if not the hope, that this could be extended to all the ILs (Petkovic et al 2011 ; Earle and Seddon 2000 ). However, in the 2000s, several biological studies highlighted a moderate-to-high toxicity of ILs towards several micro-organisms, plants, cell lines, and potentially humans (Bernot et al 2005 ; Pretti et al 2006 ; Pham et al 2008 ; Studzińska and Buszewski 2009 ; Matzke et al 2009 ; Li et al 2009 ; Coleman and Gathergood 2010 ; Frade and Afonso 2010 ; Costa et al 2017 ; Bubalo et al 2017 ; Thamke et al 2019 ; Pawłowska et al 2019 ; Leitch et al 2020a ; Leitch et al 2020b ). For example, ILs based on amino acids (Benedetto et al 2014a ), which were supposed to be more bio-friendly, turned out to have higher toxicity level than their common counterparts (Egorova et al 2015 ).…”
Section: Introductionmentioning
confidence: 99%
“…1 ) and authentic pure M8OI recapitulated the toxic effects of M8OI in the hepatic progenitor (and human cholangiocytes): an inhibition of mitochondrial oxidative phosphorylation and apoptosis ( Probert et al, 2018 ). Subsequent re-analysis of soil samples indicated that the M8OI levels in the most contaminated sites where at present in the aqueous soil extracts and originating soils at 13 mM and 0.3 mg/kg respectively ( Leitch et al, 2020 ).
Fig.
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Section: Introductionmentioning
confidence: 99%
“…In theory, a near limitless number of different methylimidazolium ionic liquids could be synthesised based on the many potential anions, but also on substitution at other positions around the imidazolium ring. However, based on registrations submitted to the European Chemicals Agency (ECHA), the total number of methylimidazolium ionic liquids used in the EU at present, is likely to be in the order of up to 60-70 [3]. Methylimidazolium-based ILs are most often proposed as solvents in a variety of industrial applications such as separations, catalysis and dissolution, with 1-ethyl-3-methylimidazolium acetate (likely used at high levels since the ECHA database indicates several variants manufactured at up to 100 tonnes/annum or manufacture levels are reported as confidential [3]).…”
Section: Introductionmentioning
confidence: 99%
“…However, based on registrations submitted to the European Chemicals Agency (ECHA), the total number of methylimidazolium ionic liquids used in the EU at present, is likely to be in the order of up to 60-70 [3]. Methylimidazolium-based ILs are most often proposed as solvents in a variety of industrial applications such as separations, catalysis and dissolution, with 1-ethyl-3-methylimidazolium acetate (likely used at high levels since the ECHA database indicates several variants manufactured at up to 100 tonnes/annum or manufacture levels are reported as confidential [3]). This methylimidazolium ionic liquid has shown outstanding performance in the fields of biomass dissolution and biopolymer processing [4].…”
Section: Introductionmentioning
confidence: 99%
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