The toxicological paradigms of aluminum and the etiology of Alzheimer's disease in the nematode<i>Caenorhabditis elegans</i>

Oliveira, Vanessa Ecléa de; Vanin, Ana Paula; Concato, Ani Carla; Tamagno, Wagner Antonio; Treichel, Helen; Kaizer, Rosilene Rodrigues

doi:10.1002/tqem.21651

Cited by 2 publications

(2 citation statements)

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“…In the human body, the Dfx chelates the free iron in serum, ferritin, and hemosiderin, not removing iron from the transferrin, hemoglobin, or cytochromes. Since herb mate extracts contain high concentrations of aluminum and iron [ 46 ], and because of the neurotoxic role of these compounds in the nervous system [ 47 ], the use of compounds that decrease the bioavailability of these toxic metals and inhibit neurotoxicity [ 48 ] is very important. Finally, Dfx can be used as an antioxidant, since its combination with natural antioxidant compounds can even potentiate its effect [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the effect of its compounds against oxidative stress, which could cause neurodegenerative diseases. Despite having health benefits, there are reports of the presence of heavy metals in extracts obtained from the infusion. One of these metals is iron (Fe), found in large amounts in herb mate. To reverse the cumulative effects of metals and Fe in the body, the use of Deferoxamine (Dfx) is indicated, being a potent chelator of Fe. In this work, we aimed to evaluate the antioxidant potential of the micro-encapsulated extract of I. paraguariensis (MEIP) supplemented with Dfx on zebrafish behavior and biochemical biomarkers. To evaluate the effect per se and the supplementation, four groups were established: the first group was the control (water); the second, fish treated with MEIP; the third group was formed of fish treated with Dfx; while the fourth group was treated with both MEIP and Dfx. When applied alone, Dfx presents an anxiogenic-like pattern on zebrafish (Danio rerio), while the MEIP shows an anxiolytic-like behavior. The antioxidant enzymes are re-modulated close to control when the MEIP + Dfx is applied. The cholinergic system shows an activation of the signaling, as well as the heme radical group formation, which is not affected by the Dfx-chelating effect. Thus, the supplementation of MEIP with Dfx is important to transform this extract into one that is safer and healthier for human consumption.

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Section: Discussionmentioning

confidence: 99%

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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“…CholNS is largely affected by different toxicants such as pesticides 22 , toxins 23 , and metals such as aluminum (Al) 15 , 24 , 25 . Al is the third most abundant metal (8%) present on the surface of the earth it is not known physiological function of this metal in mammalians 26 .…”

Section: Introductionmentioning

confidence: 99%

Cannabis sativa-based oils against aluminum-induced neurotoxicity

Alves

Tamagno

Vanin

et al. 2023

Sci Rep

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The use of terpenoid compounds in different neural-related conditions is becoming useful for several illnesses. Another possible activity of these compounds is the reduction of nervous impairment. Cannabis sativa plants are known for their concentration of two important terpenoids, the delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD and THC have central peripheral activities already described and their usage in different brain diseases, such as Alzheimer's and multiple sclerosis. Aluminum (Al) is known as an important neurotoxic compound, the physiological action of Al is not known already, and in high concentrations can lead to intoxication and cause neurotoxicity. Here we evaluated the potential effect of two different doses of CBD- and THC-rich based oils against Al-induced toxicity, in the zebrafish model. We evaluated behavioral biomarkers of the novel tank test (NTT) and social preference test (SPT), and biochemical markers: the activity of the enzyme acetylcholinesterase (AChE) and the antioxidant enzymes—catalase, superoxide dismutase, and glutathione-S-transferase. CBD- and THC-based oils were able to increase the AChE activity helping the cholinergic nervous system actuate against Al toxicity which was reflected by the behavioral biomarkers changes. We concluded that the oils have a protective effect and might be used with proposals for neurological and antioxidant impairment avoidance caused by Al intoxications.

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The toxicological paradigms of aluminum and the etiology of Alzheimer's disease in the nematodeCaenorhabditis elegans

Cited by 2 publications

References 35 publications

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Cannabis sativa-based oils against aluminum-induced neurotoxicity

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