The Trabecular Meshwork: A Basic Review of Form and Function

Abu-Hassan, Diala Walid; Acott, Ted S.; Kelley, Mary J.

doi:10.13188/2334-2838.1000017

Cited by 85 publications

(42 citation statements)

References 119 publications

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“…There may be several reasons why TM length can increase the risk of development of glaucoma. The TM is the core structure that controls IOP by regulating the outflow of aqueous humor [23]. TM function is essential for maintaining proper aqueous outflow [23].…”

Section: Discussionmentioning

confidence: 99%

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Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Choi

Cho

Kim

et al. 2021

JCM

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Glaucoma is one of the most common causes of blindness worldwide, but the risk factors of glaucoma are yet to be fully understood. We investigated the relationship between the prevalence of glaucoma and trabecular meshwork (TM) length by comparing the mean TM length of a South Korean population with that of another ethnic population. We included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography at Yonsei University Gangnam Severance Hospital between January 2015 and December 2017. We measured the distance from the scleral spur to Schwalbe’s line in patients with open and closed angles and calculated the TM length using the open- and closed-angle ratios in the general population. The mean TM length of the patients in our study was 752 ± 116 μm. Considering the compensated data, the estimated true mean TM length in the Korean population was 793 ± 76 μm, which was similar to the mean TM length of a previously evaluated Hispanic population, but differed significantly from those of previously evaluated Asian (Chinese), Caucasian, and African-American populations (p < 0.05). Our results support the hypothesis that the development of glaucoma would be affected by TM length.

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Section: Discussionmentioning

confidence: 99%

“…The TM is the core structure that controls IOP by regulating the outflow of aqueous humor [23]. TM function is essential for maintaining proper aqueous outflow [23]. It can be assumed that a short TM length indirectly indicates a smaller TM.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Choi

Cho

Kim

et al. 2021

JCM

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“…Some human diseases are accompanied by a decrease in the molecular weight of hyaluronic acid in the tissues involved. For instance, in primary open-angle glaucoma, the amount of HA decreases in trabecular meshwork, and an alteration in surface tension might be one of the consequences of the action of hyaluronic acid on the aqueous outflow [55][56][57][58]. The knowledge of changes in surface tension could help to better understand some degradation processes in the human body.…”

Section: Surface Tensionmentioning

confidence: 99%

Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

et al. 2020

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Hyaluronic acid, as a natural linear polysaccharide, has attracted researchers’ attention from its initial detection and isolation from tissues in 1934 until the present day. Due to biocompatibility and a high biodegradation of hyaluronic acid, it finds wide application in bioengineering and biomedicine: from biorevitalizing skin cosmetics and endoprostheses of joint fluid to polymeric scaffolds and wound dressings. However, the main properties of aqueous polysaccharide solutions with different molecular weights are different. Moreover, the therapeutic effect of hyaluronic acid-based preparations directly depends on the molecular weight of the biopolymer. The present review collects the information about relations between the molecular weight of hyaluronic acid and its original properties. Particular emphasis is placed on the structural, physical and physico-chemical properties of hyaluronic acid in water solutions, as well as their degradability.

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“…Unlike other IOPlowering monotherapies, LBN provides a novel dual mechanism of action for improving aqueous humor outflow by targeting the uveoscleral pathway through the action of latanoprost acid and targeting the TM/Schlemm's canal through the action of NO [19,20]. The latter action is important given the central role of the TM/ Schlemm's canal in aqueous humor outflow along with the observation of decreased NO levels in the aqueous humor and in plasma of glaucoma patients [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Chart Review on Real-World Use of Latanoprostene Bunod 0.024% in Treatment-Naïve Patients with Open-Angle Glaucoma

Okeke

Burstein

Trubnik³

et al. 2020

Ophthalmol Ther

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The Trabecular Meshwork: A Basic Review of Form and Function

Cited by 85 publications

References 119 publications

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

Retrospective Chart Review on Real-World Use of Latanoprostene Bunod 0.024% in Treatment-Naïve Patients with Open-Angle Glaucoma

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