The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Zhou, Jiang; Qian, Jun; Dong, Haiyan; Yang, Jingyi; Yu, Xiaobo; Chen, Jianzhong; Chen, Hongning; Shi, Qing; Lee, Jia

doi:10.1038/s41598-017-02054-y

Cited by 18 publications

(19 citation statements)

References 57 publications

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“…The scratched wound assay is an important tool for study of cell migration as well as metastasis. Numerous phytochemicals and herbal extract have been reported for inhibition of cellular migration which may play an important role in prevention of metastasis in cancer patients [43][44][45]. The leaf extract, BLEA has also showed inhibition of cellular migration of MCF-7 cells in this study.…”

Section: Discussionsupporting

confidence: 63%

Semecarpus Anacardium Linn. Leaf Extract Exhibits Activities Against Breast Cancer And Prolongs The Survival of Tumor Bearing Mice

Singh

Ranjan

Tripathi

et al. 2021

Preprint

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Semecarpus anacardium Linn. is a commonly used Ayurvedic medicinal plant which nuts have been described in Ayurveda and Sidda system of medicine to treat clinical ailments such as vitiligo, inflamation, microbial infection, geriatric problem, baldness and neuro related problems. In this study, anti-cancer activity of the leaves of Semecarpus anacardium Linn was evaluated for future drug development. The phytochemical screening was done by GC-MS analysis, cytotoxicity was examined using MTT assay, mode of cell death was evaluated by fluorescence microscopy and finally antitumor activity was determined in EAC cell induced tumor bearing mice. The ethyl acetate extract from the leaves of the plant induced cytotoxicity in cancer cells in a dose dependent manner (IC50: 0.57 µg/ml in MCF-7 cells) in different cancer cell lines. The non-malignant cells were relatively insensitive to the extract. The staining with acridine orange, ethidium bromide and DAPI confirmed that the extract induced apoptosis in cancer cells. Furthermore, the extract induced cell cycle arrest at G1 phase and suppressed cancer cell migration. An oral administration of the extract suppressed the tumor growth in mice model bearing ehrlich ascites carcinoma cells. The ethyl acetate extract was also found to prolong the survival of tumor bearing mice. Overall, these observations suggest the anticancer activities of the ethyl acetate extract of the leaves of S. anacardium. The study opens a new window to examine the phytochemical constituents from the leaves of the plant responsible for the anticancer activities.

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Section: Discussionsupporting

confidence: 63%

Semecarpus Anacardium Linn. Leaf Extract Exhibits Activities Against Breast Cancer And Prolongs The Survival of Tumor Bearing Mice

Singh

Ranjan

Tripathi

et al. 2021

Preprint

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“…Ginsenoside Ro is also one of the bioactive components of Shenmai injection that is often used as an adjuvant treatment for various cancers 30 . Ginsenoside Ro can suppress the HT29 cell metastasis 31 and markedly inhibits tumour growth in B16F10‐transplanted mice 32 . Oleanolic acid (OA), an aglycone of ginsenoside Ro, has been shown to inhibit the proliferation and induce apoptosis of cancer cells 33 .…”

Section: Discussionmentioning

confidence: 99%

Spectrum‐effect relationship between UPLC fingerprints and anti‐lung cancer effect of Panax ginseng

Zhou

Liu

Zhang

et al. 2020

Phytochemical Analysis

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Objectives Lung cancer has the highest mortality rate among the various types of cancer. Panax ginseng (C. A. Mey). is a popular anti‐cancer herbal supplement. The quality control of ginseng is crucial to ensure its clinical efficacy. This study aimed to establish new quality control methods for ginseng and to identify its main active components responsible for lung cancer treatment. Methods Ultra‐high‐performance liquid chromatography (UPLC) was used to establish fingerprints of 18 batches of ginseng. CCK‐8 test was performed to evaluate the inhibitory activity of ginseng on Lewis lung cancer (LLC) cells. The spectrum‐effect relationship analysis of ginseng was assessed by canonical correlation analysis (CCA) and bioactivity validation. Key findings Six common peaks were identified and the variation coefficients were determined. The 18 batches of ginseng inhibited the proliferation of LLC cells to different degrees, showing different half maximal inhibitory concentration (IC50) values. Spectrum‐effect relationship analysis showed that ginsenoside Ro is the main anti‐proliferative constituent of LLC cell. Conclusions Spectrum‐effect relationship is suitable for quality control of ginseng used for lung cancer. It is also effective in discovering the active ingredients related to the clinical efficacy of traditional Chinese medicine.

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“…The scratched wound assay is an important tool for study of cell migration as well as metastasis. Numerous phytochemicals and herbal extract have been reported for inhibition of cellular migration which may play an important role in prevention of metastasis in cancer patients (Gao et al, 2018; Jiang et al, 2017; Liang et al, 2015). The leaf extract, BLEA has also showed inhibition of cellular migration of MCF-7 cells in this study.…”

Section: Discussionmentioning

confidence: 99%

Semecarpus anacardiumLinn. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor-bearing mice

Singh¹,

Ranjan²,

Tripathi³

et al. 2020

Preprint

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Background: Semecarpus anacardium Linn. is a commonly used Ayurvedic medicinal plant. Their different parts including nuts, have various medicinal properties to treat clinical ailments such as vitiligo, inflamation, microbial infection, geriatric problem, baldness and neuro-related problems.Aim of the study: The main objective of this study was an evaluation of the anticancer activity of the leaves of Semecarpus anacardium Linn and phytochemical screening. Materials and methods: The phytochemical screening was carried out through GC-MS analysis. Cytotoxicity was examined using MTT assay whereas mode of cell death evaluated by fluorescence microscopy. Finally, antitumor activity was determined in EAC cell-induced tumorbearing mice. Results: The ethyl acetate extract induced cytotoxicity in cancer cells in a dose dependent manner (IC 50 : 0.57 µg/ml in MCF-7 cells) in different cancer cell lines. However, normal cells were relatively insensitive to the extract. Fluorescence microscopy results, confirmed that the extract induced apoptosis in cancer cells effectively. The extract induce cell cycle arrest at the G1 phase and suppressed cancer cell migration. An oral administration of the extract suppressed the tumor growth in the mice model bearing Ehrlich ascites carcinoma cells. Whereas, the ethyl acetate extract was also found to prolong the survival of tumor-bearing mice. Conclusion: Overall, these observations suggest the anticancer activities of the ethyl acetate extract of S. anacardium leaves. The study opens a new window to examine the phytochemical constituents from the leaves as a source for the anticancer compounds.

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The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Cited by 18 publications

References 57 publications

Semecarpus Anacardium Linn. Leaf Extract Exhibits Activities Against Breast Cancer And Prolongs The Survival of Tumor Bearing Mice

Semecarpus Anacardium Linn. Leaf Extract Exhibits Activities Against Breast Cancer And Prolongs The Survival of Tumor Bearing Mice

Spectrum‐effect relationship between UPLC fingerprints and anti‐lung cancer effect of Panax ginseng

Semecarpus anacardiumLinn. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor-bearing mice

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