The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Brennan, Donal J.; Ek, Sara; Doyle, Evelyn; Drew, T.; Foley, Michael; Flannelly, Grainne; O’Connor, Darran P.; Gallagher, William M.; Kilpinen, Sami; Kallioniemi, Olli; Jirström, Karin; O’Herlihy, Colm; Borrebaeck, Carl

doi:10.1016/j.ejca.2009.01.028

Cited by 76 publications

(96 citation statements)

References 24 publications

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“…We have previously shown that SOX11 is aberrantly expressed in both MCL 1 and epithelial ovarian cancer 17 in which SOX11 predicts recurrence-free survival. Although the functional effect and downstream genes activated by SOX11 are yet to be described, it is intriguing that the strong nuclear expression of SOX11 in lymphoid neoplasia appears limited to three disparate categories, which include the two mature B-cell tumors, MCL and true Burkitt's lymphoma, and immature lymphoblastic neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma

Dictor¹,

Ek²,

Sundberg³

et al. 2009

Haematologica

130

120

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BackgroundWe surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. Design and MethodsOn hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. ResultsNuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. ConclusionsIn addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.Key words: lymphoid, SOX11 transcription factors, lymphoblastic neoplasms, mantle cell lymphoma, Burkitt's lymphoma. 's lymphoma. Haematologica 2009; 94:1563-1568. doi:10.3324/haematol.2009 This is an open-access paper. Citation: Dictor M, Ek S, Sundberg M, Warenholt J, György C, Sernbo S, Gustavsson E, AbuAlsoud W, Wadström T, and Borrebaeck T. Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and BurkittStrong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma

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Section: Discussionmentioning

confidence: 99%

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma

Dictor¹,

Ek²,

Sundberg³

et al. 2009

Haematologica

130

120

View full text Add to dashboard Cite

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“…Sox4 is also overexpressed in many other types of cancers, including leukemias (Andersson et al, 2007), melanomas (Talantov et al, 2005), glioblastomas (Sun et al, 2006), medulloblastomas (Lee et al, 2002), bladder cancer (Aaboe et al, 2006) and lung cancer (Friedman et al, 2004). Similarly, Sox11 is highly expressed in medulloblastomas (Lee et al, 2002), gliomas (Weigle et al, 2005), non-B cell lymphomas (Wang et al, 2008) and epithelial ovarian tumors (Brennan et al, 2009). However, the underlying mechanism by which the Sox proteins may contribute to cancer is not fully understood.…”

Section: Research Articlementioning

confidence: 99%

TheC. elegansSoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm

et al. 2011

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SUMMARYThe proper development of multicellular organisms requires precise regulation and coordination of cell fate specification, cell proliferation and differentiation. Abnormal regulation and coordination of these processes could lead to disease, including cancer. We have examined the function of the sole C. elegans SoxC protein, SEM-2, in the M lineage, which produces the postembryonic mesoderm. We found that SEM-2/SoxC is both necessary and sufficient to promote a proliferating blast cell fate, the sex myoblast fate, over a differentiated striated bodywall muscle fate. A number of factors control the specific expression of sem-2 in the sex myoblast precursors and their descendants. This includes direct control of sem-2 expression by a Hox-PBC complex. The crucial nature of the HOX/PBC factors in directly enhancing expression of this proliferative factor in the C. elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation.

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“…We predicted its target genes, and found 147 candidates. The expressions of some target genes, such as SOX11 and TEGT, correlate with good prognosis of cancer (40,41). Worth of note is the predicted target gene RKIP (PEBP1), which is known as a metastasis suppressor (42).…”

Section: Discussionmentioning

confidence: 99%

5-Fluorouracil and oxaliplatin modify the expression profiles of microRNAs in human colon cancer cells in vitro

Bai¹

2009

Oncol Rep

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Abstract. MicroRNAs (miRNAs) have recently taken center stage in the field of human molecular oncology. Most of the chemotherapeutics are able to interfere with nucleic acid metabolism and gene expression. The purpose of this study was to determine how 5-fluorouracil (5-FU) and oxaliplatin (L-OHP) modify the expression profiles of miRNAs in HCT-8 and HCT-116 colon cancer cells and whether the pharmacodynamic mechanisms of the chemotherapeutics could rely in part on their influence on miRNA expression. The expression profiles of miRNAs were determined using a miRNA microarray containing 856 human miRNA probes. The expression of selected miRNAs was then validated by real-time RT-PCR. Fifty-six up-and 50 down-regulations of miRNA expression with statistical significance were identified in colon cancer cells following exposure to 5-FU or L-OHP compared to matched control cells. The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated. Analysis of the relevant literature indicated that, in line with the tumor suppressive activity of 5-FU and L-OHP, the six down-regulated miRNAs might function as oncogenes due to their overexpression in cancers, and some of them correlated with the poor prognosis and treatment-resistance of cancer. In conclusion, we identify the modification of miRNA expression profiles in colon cancer cells following exposure to 5-FU and L-OHP, and our results indicate that their pharmacodynamic mechanisms could rely in part on their influence on the down-regulated miRNA expression.Further studies are needed to determine whether these miRNAs and their target genes might potentially provide for novel molecular markers and act as novel targets for treatment by interference.

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The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Cited by 76 publications

References 24 publications

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma

TheC. elegansSoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm

5-Fluorouracil and oxaliplatin modify the expression profiles of microRNAs in human colon cancer cells in vitro

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