1997
DOI: 10.1038/42652
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The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

Abstract: The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all co… Show more

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Cited by 1,199 publications
(1,077 citation statements)
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References 45 publications
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“…Previous evidence suggests a potential functional redundancy between members of the p160 family (Torchia et al, 1997). The present observations suggest that each of the p160 members, in addition to CBP, exert a similar role inhibiting cell death when it is Figure 6 RAC3 overexpression inhibits caspase-9 and -3 activation.…”
Section: Discussionsupporting
confidence: 53%
“…Previous evidence suggests a potential functional redundancy between members of the p160 family (Torchia et al, 1997). The present observations suggest that each of the p160 members, in addition to CBP, exert a similar role inhibiting cell death when it is Figure 6 RAC3 overexpression inhibits caspase-9 and -3 activation.…”
Section: Discussionsupporting
confidence: 53%
“…One major link is CBP/p300 (CREB-Binding protein) that is a component of a larger complex critical for integration of several signal transduction pathways. CBP is associated with steroid-receptor coactivators (SRCs), which can also recognize ligandbound nuclear receptors (Torchia et al, 1997). The increased accessibility of the chromatin structure of the pS2 gene after IGFI and estradiol treatment, as revealed by the presence of pS2-HS1 and pS2-HS4, may be due to the recruitment of the partners from di erent signal transduction pathways in the coactivators complex.…”
Section: Discussionmentioning
confidence: 99%
“…(b) ZR75-1 cells were transfected with p86(X/S)CAT as in (a) either alone (7) or with the addition of 0.5 mg/plate of expression vectors for either TIF2 or AIB1 as indicated. Higher inputs of either expression plasmid did not increase expression levels mutant of SRC-1 that lacks the domain (AD1) required for interaction with p300/CBP (Torchia et al, 1997). This protein was largely unable to prevent oestrogen repression of the ERBB2 enhancer ( Figure 6b).…”
Section: Er Cofactors Also Activate the Erbb2 Enhancermentioning
confidence: 97%
“…The precise role of some of these factors remains to be determined, but three related 160 kDa proteins (p160 family) named SRC-1/NcoA-1, TIF2/GRIP2 and AIB1/ SRC3/ACTR/RAC3/pCIP clearly potentiate the transcriptional activity of the ER and indeed several other nuclear receptors (McKenna et al, 1999). This interaction, which is tightly ligand-dependent, is mediated by LXXLL motifs present in all of these proteins (Heery et al, 1997;Torchia et al, 1997). If these factors are also required for the activity of the ERBB2 enhancer, it is conceivable that the activated ER may compete for their binding and thereby repress ERBB2 expression.…”
Section: Er Cofactors Also Activate the Erbb2 Enhancermentioning
confidence: 99%