2024
DOI: 10.1101/2024.09.18.613279
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The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output

Alexandra J. Trevisan,
Katie Han,
Phillip Chapman
et al.

Abstract: Neural circuits in the spinal cord are composed of diverse sets of interneurons that play crucial roles in shaping motor output. Despite progress in revealing the cellular architecture of the spinal cord, the extent of cell type heterogeneity within interneuron populations remains unclear. Here, we present a single-nucleus transcriptomic atlas of spinal V1 interneurons across postnatal development. We find that the core molecular taxonomy distinguishing neonatal V1 interneurons perdures into adulthood, suggest… Show more

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