“…For example, strategies that focus on the services or programs of only one kind of professional or organization have not been adequate to solve problems like low birth weight, substance abuse, depression, teen pregnancy, asthma, and inadequate access to care because these problems are interrelated and depend on a broad array of social, economic, environmental, political, emotional, and biologic determinants. [47][48][49][50] Problems that require comprehensive actions have been difficult to solve when needed participants have not been involved or when programs, organizations, and/ or policies work at cross-purposes with each other. 51 The tremendous diversity in the populations affected by health problems, and in the local contexts in which these problems occur, have limited the effectiveness of top-down, "one-size-fits-all" solutions.…”