The translational landscape in articular chondrocytes treated with interleukin-1 reveals novel potential players in osteoarthritis

Kolupaeva, Victoria G.; Katsara, Olga; Attur, M.

doi:10.1016/j.joca.2018.02.173

Cited by 1 publication

(2 citation statements)

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“…Recently ribosome profiling coupled to protein mass-spectrometry demonstrated that treatment of chondrocytic cells with IL-1β induced the preferential translation of proteins associated with inflammatory responses and oxidative stress [ 53 ▪▪ ]. IL-1β -induced preferential translation of osteoarthritis-related proteins in chondrocytes was suggested to be mediated by their 5′ untranslated regions [ 54 ].…”

Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

“…However, ribosome translation activity can be connected to ER stress and the UPR via inactivation of eukaryotic translation initiation factor (eIF) 2α and inhibition of 80S ribosome assembly [ 58 , 62 ]. Recent evidence demonstrates that translation of catabolic proteins in chondrocytic cells is preferred in osteoarthritis-mimicking environments [ 53 ▪▪ , 54 ]. The finding that mechanisms of such preferential translation can also include heterogeneity of the cellular ribosome pool is an exciting development that may further unveil how cells in joints tissues can translationally respond to changes in their environment at the protein level (Fig.…”

Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

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Ribosome dysfunction in osteoarthritis

Akker

Caron

Peffers

et al. 2022

Current Opinion in Rheumatology

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Purpose of review Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis. Recent findings We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation. Summary The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments.

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Section: The Ribosome In Osteoarthritismentioning

confidence: 99%