The translationally controlled tumour protein (TCTP)

Bommer, Ulrich‐Axel; Thiele, B

doi:10.1016/s1357-2725(03)00213-9

Cited by 404 publications

(363 citation statements)

References 29 publications

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“…It has been demonstrated that mollusk hepatopancreas represented a significant target for bacterial stimuli and toxic metal exposure [33e35]. HSP70 and TCTP, as members of HSPs family, were both implicated in the protection of cells against various abiotic stress and in the innate immune responses against bacterial challenge [3,36]. In the present study, no significant difference in the expression of MgHSPA12A was detected in hepatopancreas of mussels post V. anguillarum injection.…”

Section: Discussioncontrasting

confidence: 51%

“…According to their molecular masses and functions, HSPs were divided into several families, including HSP100, HSP90, HSP70, HSP60, and the small HSPs (sHSPs) [2]. Heat shock protein 70 (HSP70) and the translationally controlled tumor protein (TCTP) are both highly conserved protein widely existed in all eukaryotic organisms [3,4]. Heat shock 70 kDa protein 12A (HSPA12A) is a novel and atypical member of HSP70 family possibly with highly specialized function that might go beyond the HSP chaperone function [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Heat shock 70 kDa protein 12A (HSPA12A) is a novel and atypical member of HSP70 family possibly with highly specialized function that might go beyond the HSP chaperone function [5,6]. The solution structure of TCTP from fission yeast indicated its similarity to a family of small chaperone proteins [3,7], and a more recent report confirmed that TCTP is a novel HSP with chaperone-like activity [8]. As members of HSPs family, HSPA12A…”

Section: Introductionmentioning

confidence: 99%

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The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge

You

Ning²,

Liu³

et al. 2013

Fish & Shellfish Immunology

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a b s t r a c tHeat shock 70 kDa protein 12A (HSPA12A) is an atypical member of HSP70 family, and the translationally controlled tumor protein (TCTP) is a novel HSP with chaperone-like activity. They are both involved in protecting organisms against various stressors. In the present study, the cDNAs of HSPA12A and TCTP (called MgHSPA12A and MgTCTP) were identified from Mytilus galloprovincialis by RACE approaches. The full-length cDNA of MgHSPA12A and MgTCTP encoded a peptide of 491 and 171 amino acids, respectively. Real-time PCR was employed to analyze the tissue distribution and temporal expression of these two genes after bacterial challenge and cadmium (Cd) exposure. It was found that the transcripts of MgHSPA12A and MgTCTP were dominantly expressed in gonad and muscle, respectively. The expression level of MgTCTP at 48 h post Vibrio anguillarum challenge was detected to be significantly up-regulated in hepatopancreas (P < 0.05). As concerned to Cd exposure, 2.0-fold increase of MgHSPA12A expression compared to that of the control was observed at 48 h in 5 mg/L Cd 2þ -treated group, while the expression levels of MgTCTP were significantly decreased after exposed to both 5 and 50 mg/L Cd 2þ for 24 h and 96 h.These results suggested the potential involvement of MgHSPA12A and MgTCTP in the mediation of the immune responses and environmental stress in mussels.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge

You

Ning²,

Liu³

et al. 2013

Fish & Shellfish Immunology

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“…This reflects the fact that by now, many functional aspects of this protein have been revealed, many of which are highly relevant to core biological and medical problems. The recent increasing interest in this protein is also reflected by the fact that 15 review articles on TCTP have already been published, all but two (Bommer and Thiele 2004;Telerman and Amson 2009) within the last 5 years. However, most of these articles focus on specific aspects of the TCTP literature, and they are spread over a wide range of journals.…”

Section: Introductionmentioning

confidence: 99%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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“…TCTP is a highly conserved protein and abundantly expressed in eukaryotes. It is reported as multifunctional to participate in numerous cellular processes including cell growth, survival, development, protein synthesis, immune response, tumor reversion, transcription regulation, and induction of pluripotent stem cells or apoptosis (Bommer and Thiele 2004). Comparing to normal tissue, the level of TCTP is increased in many human cancer tissues, such as breast, colorectal, prostate and lung cancer (Arcuri et al 2004;Deng et al 2006;Kim et al 2008;Slaby et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomics analysis of global cellular stress responses to hydroxyurea-induced DNA damage in HeLa cells

et al. 2014

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Both environmental agents and spontaneous cellular events cause serious DNA damage, threatening the integrity of the genome. In response to replication stress or genotoxic agents triggered DNA damage, degradation of p12 subunit of DNA polymerase delta (Pol d) results in an inter-conversion between heterotetramer (Pol d4) and heterotrimer (Pol d3) forms and plays a significant role in DNA damage response in eukaryotic cells. In this work, we used mass spectrometry-based proteomic approach to identify those cellular stress response protein changes corresponding to the degradation of p12 in DNAdamaged HeLa cells by the treatment with hydroxyurea (HU). A total of 736 ± 13 proteins in non-treated control group and 741 ± 19 protein spots in HUtreated cells were detected, of which 34 proteins (17 up-regulated and 17 down-regulated) exhibited significantly altered protein expression levels. Their physiological roles are mainly associated with cellular components, molecular functions, and biological processes by gene ontology analysis, among which 21 proteins were mapped to KEGG pathways. They are involved in 5 primary pathways with the subsets involving 16 secondary pathways by further KEGG analysis. More interestingly, the up-regulation of translationally controlled tumor protein was further identified to be associated with p12 degradation by Western blot analysis. Our works may enlarge and broaden our view for deeply understanding how global cellular stress responds to DNA damage, which could contribute to the etiology of human cancer or other diseases that can result from loss of genomic stability.

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The translationally controlled tumour protein (TCTP)

Cited by 404 publications

References 29 publications

The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge

The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Comparative proteomics analysis of global cellular stress responses to hydroxyurea-induced DNA damage in HeLa cells

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