The transport and metabolism of l-proline-14C in the rat in vivo

Greth, Warren E.; Thier, Samuel O.; Segal, Stanton

doi:10.1016/0026-0495(78)90142-7

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…We also observed a slight increase in glycemia in the Sev group with respect to uninfected controls. It has been previously shown that proline can be a precursor for gluconeogenesis [13] and that lactate is an allosteric regulator of proline oxidase (the first enzyme in the proline oxidation pathway). On this basis, it was suggested that lactate may influence the hepatic availability of proline, which can be used for glucose biosynthesis, resulting in increased glycemia [14].…”

Section: Discussionmentioning

confidence: 99%

Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?

et al. 2019

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Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and oxidative stress. On this basis, we investigated a possible relationship between prolinemia and severity of T. cruzi infection in chronic patients, as reported here. The study population consisted of 112 subjects, separated into 83 chronically T. cruzi-infected patients and 29 age-matched healthy volunteers (control) of both sexes, recruited at the Chagas Disease Service from the Department of Cardiology, Hospital Provincial del Centenario de Rosario (Rosario, Argentina). Chagasic patients were separated into three groups: chronic asymptomatic, mild/moderate, and severe chronic chagasic cardiomyopathy (CCC) subjects. We observed a significant decrease of 11.7% in prolinemia in chagasic patients when compared to controls. Further analysis within the three groups of chagasic patients also revealed a statistically significant decrease of prolinemia in severe CCC patients compared to controls, showing a relative difference of 13.6% in proline concentrations. These data point to the possibility that collagen—which participates in the healing process of cardiac tissue—and proline metabolism in the myocardium could constitute new factors affecting the evolution of Chagas disease.

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Section: Discussionmentioning

confidence: 99%

Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?

et al. 2019

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Acetic Acid, Halogenated Derivatives

Morris

Bost

2002

Kirk-Othmer Encyclopedia of Chemical Technology

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The most important of the halogenated derivatives of acetic acid is chloroacetic acid, which has wide applications as an industrial chemical intermediate in the manufacture of cellulose ethers, herbicides, and thioglycolic acid. Most chloroacetic acid is produced by the chlorination of acetic acid. Chloroacetic acid is extremely corrosive and will cause serious chemical burns. It is readily absorbed through the skin; contamination of 5–10% of the skin is usually fatal. Sodium chloroacetate, C 2 H 2 ClO 2 Na, is produced by reaction of chloroacetic acid with sodium hydroxide or sodium carbonate. Dichloroacetic acid, C 2 H 2 Cl 2 O 2 , is a reactive intermediate in organic synthesis. It has been manufactured by the chlorination of acetic and chloroacetic acids and by other means. Trichloroacetic acid, C 2 HCl 3 O 2 , forms white deliquescent crystals. Sodium trichloroacetate, C 2 Cl 3 O 2 Na, is used as a herbicide. Chloroacetyl chloride (ClCH 2 COCl) is the corresponding acid chloride of chloroacetic acid, and is manufactured by reaction of chloroacetic acid with chlorinating agents. Much of the chloroacetyl chloride produced is used captively as a reactive intermediate. It is useful in many acylation reactions and in the production of adrenalin, diazepam, and chloroacetic anhydride. Two chloroacetate esters of industrial importance are methyl chloroacetate, C 3 H 5 ClO 2 , and ethyl chloroacetate, C 4 H 7 ClO 2 . Both are used as agricultural and pharmaceutical intermediates. Other derivatives are bromoacetic acid, dibromoacetic acid, tribromoacetic acid, iodoacetic acid, diiodoacetic acid, and triiodoacetic acid.

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