The Transposons of the Sea Urchin Strongylocentrotus intermedius Agassiz, 1863: In Silico Versus In Vitro

Лебедев, Е. Е.; Ostromyshenskii, D. I.; Solovyeva, A. I.; Дроздов, А. Л.; Podgornaya, O. I.; Adonin, Leonid S.

doi:10.1134/s1063074019060051

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“…The latest analysis of the sea urchin genome showed that known transposons 3 occupy about 15% of the genome, including the major class DNA transposons ( Figure 4 ; Lebedev et al, 2019 ). The percentage of genome occupied by transposons is higher than that of the worm Caenorhabditis elegans but less than that of fruit fly or human ( Kazazian and Moran, 2017 ).…”

Section: Regulatory Network Based On Non-coding Rnasmentioning

confidence: 99%

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Sea Urchin as a Universal Model for Studies of Gene Networks

2021

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The purple sea urchin Strongylocentrotus purpuratus has been used for over 150 years as a model organism in developmental biology. Using this model species, scientists have been able to describe, in detail, the mechanisms of cell cycle control and cell adhesion, fertilization, calcium signaling, cell differentiation, and death. Massive parallel sequencing of the sea urchin genome enabled the deciphering of the main components of gene regulatory networks during the activation of embryonic signaling pathways. This knowledge helped to extrapolate aberrations in somatic cells that may lead to diseases, including cancer in humans. Furthermore, since many, if not all, developmental signaling pathways were shown to be controlled by non-coding RNAs (ncRNAs), the sea urchin organism represents an attractive experimental model. In this review, we discuss the main discoveries in the genetics, genomics, and transcriptomics of sea urchins during embryogenesis with the main focus on the role of ncRNAs. This information may be useful for comparative studies between different organisms, and may help identify new regulatory networks controlled by ncRNAs.

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Section: Regulatory Network Based On Non-coding Rnasmentioning

confidence: 99%

“… The percent content of transposable elements (TE) in genomes of the sea urchin S. purpuratus and other invertebrates. TE classes are marked with a color: nonLTR SINE – blue; LINE – red; LTR TE – yellow; DNA transposons – green; non-annotated repeats – lilac (from Lebedev et al, 2019 ). …”

Section: Regulatory Network Based On Non-coding Rnasmentioning

confidence: 99%