The Treatment of Acute Gold and Arsenic Poisoning

Cohen, Abraham G.

doi:10.1001/jama.1947.02880110015004

Cited by 38 publications

(7 citation statements)

References 6 publications

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“…It has been reported that BAL reacts with gold (Brown et al 1979) and is used as an antidote for gold intoxication (Cohen et al 1947;Lockie et al 1947;Ragan and Boots 1947). However, DMPS appears to be more advantageous as an antidote against gold toxicity than BAL because of the lesser toxicity of DMPS (Gabard et al 1980).…”

Section: Discussionmentioning

confidence: 99%

“…The adverse reactions in these cases have been treated by various procedures. 2,3-Dimercaptopropanol (BAL) has been used to prevent the development of toxic side effects (Cohen et al 1947;Lockie et al 1947;Ragan and Boots 1947;England and Smith 1972). Gabard (1980) reported that orally administered sodium 2,3-dimercaptopropane sulphonate (DMPS) reduced the concentration of gold in rats treated with AuroDetoxin and increased the urinary excretion of the metal.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats

et al. 1991

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The protective effects of various chelating agents such as D-penicillamine (D-PEN), 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane sulphonate (DMPS), and N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine), on the renal damage induced by gold sodium thiomalate (AuTM) in rats were studied. Rats were injected i.v. with AuTM at doses of 0.026, 0.066, 0.132, and 0.198 mmol/kg. Urinary excretion of protein, aspartate aminotransferase (AST), and glucose in rats injected with AuTM significantly increased compared to the control levels within 1 day after the injection and thereafter decreased nearly to the control levels at 3 or 7 days. Gold was excreted rapidly during the first day after AuTM injection and excreted gradually thereafter. The concentrations of gold in the kidney and liver at 1 or 7 days after AuTM administration were approximately dose dependent. Treatment with D-PEN, DMSA, DMPS, and bucillamine (1.2 mmol/kg) significantly prevented increases in the urinary excretion of protein, AST, and glucose and the BUN level after AuTM (0.026 mmol/kg) injection. The injection of the chelating agents after AuTM administration showed that D-PEN, DMSA, and DMPS enhanced mainly the urinary excretion of gold and that bucillamine enhanced mainly the fecal excretion of the metal. These chelating agents significantly decreased the gold concentrations in the kidney and liver. The findings suggest that the chelating agents tested can ameliorate the renal damage induced by AuTM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats

et al. 1991

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“…The therapeutic efficacy of dimercaprol in some of the toxic manifestations of arsenical poisoning has been dramatic. Its effect on arsenical dermatitis has been good (Carlton et al, 1948), and on gold thrombocytopenia and granulocytopenia encouraging (Lockie et al, 1947;Cohen et al, 1947;Ragan and Boots, 1947).…”

Section: Discusionmentioning

confidence: 99%

Purpura and Pancytopenia Complicating Arsenotherapy

Nelson¹

1952

BMJ

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“…This substance has the ability of increasing the excretion of arsenic and desintoxicat.ing, in cases of arsenic poisoning (13,16,19,24). This quality of BAL has later on shown to be applicable t o several kinds of poisoning with special heavy metals, such as gold (6), mercury (3, 8), lead (1,21), chrome, nickel, antimony and bismuth (3). BAL has been in effective in thallium and selenium poisoning.…”

Section: Mac Mahon Murphy and Batesmentioning

confidence: 99%

An Attempt of Excreting Injected Thorotrast in Rabbits by 2, 3-Dimercaptopropanol. (Bal)

Nordenstrom-Blomqvist

1950

Acta Radiologica

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The Treatment of Acute Gold and Arsenic Poisoning

Cited by 38 publications

References 6 publications

Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats

Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats

Purpura and Pancytopenia Complicating Arsenotherapy

An Attempt of Excreting Injected Thorotrast in Rabbits by 2, 3-Dimercaptopropanol. (Bal)

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