The treatment of acute post-transfusion hepatitis C with recombinant interferon-alpha

Palmović, D; Kurelac, Ivan; Crnjaković-Palmović, Jasenka

doi:10.1007/bf01716714

Cited by 21 publications

(16 citation statements)

References 15 publications

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“…27 Several studies have evaluated the efficacy of IFN therapy for acute HCV infection. [28][29][30][31][32][33][34][35][36][37][38] However, all studies have substantial limitations. The small number of patients (also in the present study) reflects the rarity of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies included primarily patients with asymptomatic transfusion-associated acute HCV infection. [28][29][30][31][32][33][34][35][36] Treatment protocols were different with respect to the dose and duration of therapy. Some studies used IFN ␤.…”

Section: Discussionmentioning

confidence: 99%

“…32,33 More importantly, older studies measured outcome not on the basis of viral parameters but by the normalization of ALT levels. 29,[34][35][36] An unknown variable is the time of initiation of therapy with respect to the onset of symptoms or the time of infection. In the German study, 17 the time from exposure to treatment was 89 days (mean, with a range of 30-112 d).…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load

Hofer

Watkins-Riedel

Janata³

et al. 2003

Hepatology

185

153

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Early interferon (IFN) therapy prevents viral persistence in acute hepatitis C, but in view of the resulting costs and morbidity patients who really need therapy have to be identified. Twelve consecutive patients with acute hepatitis C (9 women, 3 men, mean age: 39.5 ؎ 18.8 y, genotype 1: 7, genotype 3a: 3, 2 could not be genotyped) were studied. The sources of infection were medical procedures in 6, sexual transmission in 3, and intravenous drug abuse in 3 patients. N atural history of acute hepatitis C virus (HCV) infection is variable. Progression to chronic hepatitis occurs in 50% to 84% of cases. [1][2][3][4][5][6][7][8][9] This variation can be partly explained by the mode of transmission of HCV, viral factors, and by the ability of the host to mount a strong T-cell response to eliminate the virus. Acute HCV infection generally has a mild course, most cases are asymptomatic, and fulminant hepatic failure is very rare. 10,11 The long-term sequelae of chronic hepatitis are the subject of ongoing discussions. Carefully conducted epidemiologic studies in well-documented cases of acute hepatitis C indicate that disease follows a very mild course and that occurrence of cirrhosis within the first 25 years after infection is rare. 2,3,7 Treatment of chronic hepatitis C, especially in patients infected with genotype 1 or 4, is still unsatisfactory. Despite improvements in response rates, current combination therapy with pegylated interferon (IFN) alfa-2a or -2b and ribavirin for chronic hepatitis C infection yields response rates from 54% to 56%. 12,13 Prevention of chronicity by early antiviral treatment thus may be important. Because of the infrequent nature of acute hepatitis C the impact of early antiviral therapy has not been well studied and is conflicting. 14 Only in 2 of 6 controlled trials using 3 MU IFN-2b 3 times a week for 6 to 24 weeks 15 eradication of HCV RNA was assessed. In general, transition to chronicity was not different from untreated controls. Only one study using 10 MU of IFN-2b until normalization of transaminase levels reported an 82% sustained virologic response. 16 A recent study 17 using 5 MU IFN alfa-2b for 6 months showed a 98% HCV eradication in Abbreviations: HCV, hepatitis C virus; IFN, interferon; ALT, alanine transaminase. From the

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load

Hofer

Watkins-Riedel

Janata³

et al. 2003

Hepatology

185

153

View full text Add to dashboard Cite

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“…Several trials exist, both controlled [61][62][63][64][65][66] and uncontrolled, [67][68][69][70] using IFN in the setting of acute HCV infection. Nearly all are problematic because of small numbers of patients and insufficient data on important parameters such as time following exposure and other inclusion criteria, type of IFN and dose used, definition of response, and follow-up periods.…”

Section: Treatment Of Acute Hcv Infectionmentioning

confidence: 99%

Acute Hepatitis C

2001

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“…Until 2012 only a few travel associated HEV cases per year were registered [25,26]. Even so, HEV has been detected in domestic swine and wild boars [8,27] resulting in a possibility of viral spread to humans [28].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?

Rode

Jemeršić

Brnić

et al. 2014

Eur J Clin Microbiol Infect Dis

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The treatment of acute post-transfusion hepatitis C with recombinant interferon-alpha

Cited by 21 publications

References 15 publications

Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load

Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load

Acute Hepatitis C

Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?

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