The Treatment of Amyotrophic Lateral Sclerosis With Vitamin E (Tocopherols)

Wechsler, I. S.

doi:10.1097/00000441-194012000-00005

Cited by 34 publications

(5 citation statements)

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“…Specifically, the studies by Camu et al (2014) and Karam et al (2013) confirmed the protective role of vitamin D [60,61]. However, we found three studies that reported questionable results [62][63][64], and one study that did not confirm the role of vitamin D in ALS [65]. The study of Camu et al ( 2014) described a cellular model of ALS (isolated motoneurons of the spinal cord of transgenic mice embryos) and ALS patients.…”

Section: Vitamin Dmentioning

confidence: 68%

“…The authors reviewed three types of comparisons: vitamin D levels in ALS patients versus non-ALS/healthy controls, the relationship between the vitamin D levels and survival in ALS patients, and the survival of patients receiving dietary supplements containing vitamin D and not receiving such dietary supplements. As a result, the authors obtained rather contradictory results in the studied articles, which do not allow us to speak unambiguously about the prognostic role of the serum vitamin D levels in the survival of ALS patients [62]. Yeshokumar et al (2015) analyzed studies on the neuroprotective role of vitamin D in cultured motor neurons in vitro and showed that vitamin D enhanced the action of the glial brain neurotrophic growth factors and protected the motor neurons from Fas-induced cell death in the culture [63].…”

Section: Vitamin Dmentioning

confidence: 92%

“…Is likely to reduce the risk of ALS [56][57][58][59][60][61][62][63][64][65][66] Vitamin E (alphatocopherol) Decrease in neuroinflammation and oxidative stress; participation in redox processes (antioxidant function, preventing lipid peroxidation, and reducing free radical reactions in rapidly dividing cells); protection of vitamin A from oxidation, which contributes to the growth of the stimulating activity of vitamin A; participation in the regulation of tissue regeneration; participation in the regulation of neuronal excitability and neuroinflammation; participation in the regulation of aging processes; participation in the synthesis of hormones; slowing down the aging process and protection against oncopathology; participation in maintaining the normal functioning of skeletal muscles; reduction of muscle tissue degeneration processes; participation in energy metabolism and thrombogenesis; participation in the formation of collagen and elastin fibers (strengthening the walls of cerebral vessels); participation in the formation of hemoglobin; reduction of muscle tissue degeneration processes.…”

Section: Nutrient Function In the Cns Role In The Development Of Als Authorsmentioning

confidence: 99%

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Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Goncharova

Davydova²,

Попова³

et al. 2021

Nutrients

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Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there is still no single concept. The study of ALS risk factors can help to understand the mechanism of this disease development and, possibly, slow down the rate of its progression in patients and also reduce the risk of its development in people with a predisposition toward familial ALS. The interest of researchers and clinicians in the protective role of nutrients in the development of ALS has been increasing in recent years. However, the role of some of them is not well-understood or disputed. The objective of this review is to analyze studies on the role of nutrients as environmental factors affecting the risk of developing ALS and the rate of motor neuron degeneration progression. Methods: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications using keywords and their combinations. We analyzed all the available studies published in 2010–2020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical cases, and meta-analyses, involving ALS patients and studies on animal models of ALS. This review demonstrated that the following vitamins are the most significant protectors of ALS development: vitamin B12, vitamin E > vitamin C > vitamin B1, vitamin B9 > vitamin D > vitamin B2, vitamin B6 > vitamin A, and vitamin B7. In addition, this review indicates that the role of foods with a high content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a big part in ALS development. Conclusion: The inclusion of vitamins and a ketogenic diet in disease-modifying ALS therapy can reduce the progression rate of motor neuron degeneration and slow the rate of disease progression, but the approach to nutrient selection must be personalized. The roles of vitamins C, D, and B7 as ALS protectors need further study.

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Section: Vitamin Dmentioning

confidence: 68%

Section: Vitamin Dmentioning

confidence: 92%

Section: Nutrient Function In the Cns Role In The Development Of Als Authorsmentioning

confidence: 99%

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Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Goncharova

Davydova²,

Попова³

et al. 2021

Nutrients

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“…The first study of an antioxidant agent (vitamin E) for ALS was published in 1940. 53 This study had several critical design flaws and remains an example of the need for controls and blinding. Included in the multiple vitamin E responders was Lou Gehrig himself, who reportedly "improved" with treatment.…”

Section: Antioxidant/mitochondrial Preservation Drugsmentioning

confidence: 99%

“…Included in the multiple vitamin E responders was Lou Gehrig himself, who reportedly "improved" with treatment. 53,54 Despite continuing his treatment with high doses of oral and injected vitamin E, he passed away one year later. 54 Interest in vitamin E was rekindled due to delayed disease onset in the ALS SOD1 mouse model.…”

Section: Antioxidant/mitochondrial Preservation Drugsmentioning

confidence: 99%

Amyotrophic Lateral Sclerosis: Drug Therapy from the Bench to the Bedside

Gibson

Bromberg

2012

Semin Neurol

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Amyotrophic lateral sclerosis (ALS) is an unrelenting progressive neurodegenerative disease causing progressive weakness, ultimately leading to death. Despite aggressive research, the pathways leading to neuronal death are incompletely understood. Riluzole is the only drug clinically proven to enhance survival of ALS patients, but its mechanism of action is not clearly understood. In this article, the proposed pathophysiology of ALS is reviewed including glutamate excitotoxicity, oxidative stress, mitochondrial dysfunction, autoimmune mechanisms, protein aggregation, SOD1 accumulation, and neuronal death. Based on these mechanisms, past major ALS drug studies will be reviewed as well as promising current ALS drug studies, focusing on the advancement of these studies from the bench to the patient's bedside.

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Use of Alpha Tocopherol in the Treatment of Neuromuscular Disorders

Lubin¹

1942

Arch Intern Med

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The Treatment of Amyotrophic Lateral Sclerosis With Vitamin E (Tocopherols)

Cited by 34 publications

References 0 publications

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis: Drug Therapy from the Bench to the Bedside

Use of Alpha Tocopherol in the Treatment of Neuromuscular Disorders

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