The Treatment of Aortic Valve Stenosis in Intermediate and Low-Risk Patients—When, How and Where

Ribichini, Flavio; Ferrero, Valeria

doi:10.3390/jcm11041073

JCM

2022

DOI: 10.3390/jcm11041073

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The Treatment of Aortic Valve Stenosis in Intermediate and Low-Risk Patients—When, How and Where

Flavio Ribichini

Valeria Ferrero

Abstract: Until now, treatment of severe aortic stenosis (AS) is recommended after the disease becomes symptomatic or causes “silent” damages such as myocardial dysfunction [...]

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Cited by 4 publications

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Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis

Fallahtafti,

Soleimani,

Ebrahimi

et al. 2024

Clinical Cardiology

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BackgroundTranscatheter aortic valve implantation (TAVI) has been increasingly used in patients with severe aortic stenosis (AS). Since coronary artery disease (CAD) is common among these patients, it is crucial to choose the best method and timing of revascularization. This study aims to compare different timing strategies of percutaneous coronary intervention (PCI) in patients with severe AS undergoing TAVI to clarify whether PCI timing affects the patients' outcomes or not.MethodsA frequentist network meta‐analysis was conducted comparing three different revascularization strategies in patients with CAD undergoing TAVI. The 30‐day all‐cause mortality, in‐hospital mortality, all‐cause mortality at 1 year, 30‐day rates of myocardial infarction (MI), stroke, and major bleeding, and the need for pacemaker implantation at 6 months were analyzed in this study.ResultsOur meta‐analysis revealed that PCI during TAVI had higher 30‐day mortality (RR = 2.46, 95% CI = 1.40–4.32) and in‐hospital mortality (RR = 1.70, 95% CI = [1.08–2.69]) compared to no PCI. Post‐TAVI PCI was associated with higher 1‐year mortality compared to other strategies. While no significant differences in major bleeding or stroke were observed, PCI during TAVI versus no PCI (RR = 3.63, 95% CI = 1.27–10.43) showed a higher rate of 30‐day MI.ConclusionOur findings suggest that among patients with severe AS and CAD undergoing TAVI, PCI concomitantly with TAVI seems to be associated with worse 30‐day outcomes compared with no PCI. PCI after TAVI demonstrated an increased risk of 1‐year mortality compared to alternative strategies. Choosing a timing strategy should be individualized based on patient characteristics and procedural considerations.

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Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis

Fallahtafti,

Soleimani,

Ebrahimi

et al. 2024

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

Optimal timing for percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

Lunardi

Venturi²,

Sole³

et al. 2022

International Journal of Cardiology

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Choosing transcatheter aortic valve replacement in porcelain aorta: outcomes versus surgical replacement

Ribichini

Ferrero

Pesarini

2023

European Journal of Cardio-Thoracic Surgery

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The Treatment of Aortic Valve Stenosis in Intermediate and Low-Risk Patients—When, How and Where

Abstract: Until now, treatment of severe aortic stenosis (AS) is recommended after the disease becomes symptomatic or causes “silent” damages such as myocardial dysfunction [...]

Cited by 4 publications

References 9 publications

Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis

Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis

Optimal timing for percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

Choosing transcatheter aortic valve replacement in porcelain aorta: outcomes versus surgical replacement

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