The treatment of asthma by inhalation of aerosol of aminophyllin

Prigal, Samuel J.; Brooks, Alan M.; Harris, Raymond

doi:10.1016/0021-8707(47)90061-0

Cited by 22 publications

(3 citation statements)

References 11 publications

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“…Two concentrations of aminophylline were prepared by dilution with saline 10 mL to 12.5 mg/mL (125 mg) and 25 mg/mL (250 mg), respectively. The dose of aminophylline chosen in this experiment was used in the study by Prigal et al 12 In group 4, verapamil 0.1 mg/kg·min was administered IV during aminophylline inhalation to inhibit calcium influx into the diaphragm muscle. 14 Thirty minutes after the start of inhalation in each group, HR, MAP, Pdi, Edi-cru, and Edi-cost were measured.…”

Section: Methodsmentioning

confidence: 99%

“…[3][4][5][6][7] Among these drugs, aminophylline IV, a methylxanthine methyltransferase compound, has been widely used to increase contractility of fatigued diaphragm in healthy subjects 8 and in patients with chronic obstructive pulmonary disease (COPD). 9 Early studies [10][11][12] suggested the efficacy of an inhaled form of methylxanthine, but, according to a MEDLINE search (key terms: aminophylline, methylxanthine, inhalation, and diaphragmatic fatigue; years: , this modality has not been used to treat diaphragmatic fatigue.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study

Fujii

2003

Current Therapeutic Research

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Background: Diaphragmatic fatigue may contribute to the development of respiratory failure. Although aminophylline administered IV has been widely used to treat diaphragmatic fatigue, to date it has not been used in aerosol formulation for this purpose.Objective: The aim of this study was to assess the efficacy of inhaled aminophylline on contractility of fatigued diaphragm in an experimental canine model.Methods: This open-label, dose-ranging, pharmacologic study was conducted at the Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba (Ibaraki, Japan). Diaphragmatic fatigue was induced in healthy, male, mongrel dogs by intermittent supramaximal bilateral electrophrenic stimulation at a low frequency (20 Hz) applied for 30 minutes. Immediately after the end of the fatigue-producing period, group 1 received inhaled vehicle only, group 2 received inhaled aminophylline 12.5 mg/mL, group 3 received inhaled aminophylline 25 mg/mL, and group 4 was infused with verapamil 0.1 mg/kg·min during inhalation of aminophylline 25 mg/mL. Diaphragmatic contractility was assessed using transdiaphragmatic pressure (Pdi).Results: Twenty-eight dogs were used in the study (7 dogs were assigned to each treatment group). When fatigue was established, Pdi at low-frequency stimulation decreased significantly from baseline in all groups (all P Ͻ 0.05), and no significant change in Pdi was found at high-frequency stimulation. In groups 2 and 3, during aminophylline inhalation, Pdi at 20-Hz stimulation increased significantly from fatigued values (both P Ͻ 0.05). Pdi increased significantly more in group 3 than in group 2 (P Ͻ 0.05). In group 4, infusion of verapamil offset the increase in Pdi seen with aerosolized aminophylline in fatigued diaphragm. The integrated electrical activity of the diaphragm did not change significantly in any group.Conclusions: Inhaled aminophylline significantly improved contractility of fatigued diaphragm in a dose-related manner in this experimental canine model CURRENT THERAPEUTIC RESEARCH(P Ͻ 0.05). Its potent effect may be caused by transmembrane calcium movement. (Curr Ther Res Clin Exp. 2003;64:725-732)

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study

Fujii

2003

Current Therapeutic Research

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“…The majority of the work reported occurred in the late 1940s (Segal, 1944;Prigal et al, 1947;Segal et al, 1949;Taplin et al, 1949). In 1976 Stewart and Block proposed several hypotheses as to why this method of delivering the drug had no therapeutic role.…”

Section: The Use Of Aminophylline By Inhalationmentioning

confidence: 99%

The use of aminophylline by inhalation.

Thompson¹,

Kemp²,

Mcallister³

et al. 1982

Brit J Clinical Pharma

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Clinical aerosols II. Therapeutic aerosols

Lourenço¹

1982

Archives of Internal Medicine

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The current uses of clinical aerosols such as water, saline, mucolytics, bronchodilators, cromolyn sodium, corticosteroids, and antimicrobials have been reviewed. The benefits of water, saline, and detergent aerosols continue to be surrounded by uncertainty and controversy. Aerosolized mucolytic and proteolytic agents have not been conclusively shown to be of substantial value in the improvement of respiratory disorders. Favorable bronchodilator therapy is achieved with aerosols of certain sympathomimetic and anticholinergic agents. However, successful therapy depends on the dose administered and the site of aerosol deposition in the lung. The prophylactic use of cromolyn sodium in patients with asthma is another useful application of aerosols. Topically active corticosteroid aerosols are increasingly being used since they may reduce risks of systemic effects from corticosteroids. Research on uncommonly aerosolized agents has widened the spectrum of therapeutic applications of aerosols.

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The treatment of asthma by inhalation of aerosol of aminophyllin

Cited by 22 publications

References 11 publications

Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study

Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study

The use of aminophylline by inhalation.

Clinical aerosols II. Therapeutic aerosols

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