The Treatment of Chlorosis by Iron and some Other Drugs

Stockman, Ralph

doi:10.1136/bmj.1.1687.881

Cited by 30 publications

(10 citation statements)

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“…Use of parenteral iron to treat anemia dates back more than a century, but early treatment administered colloidal iron which limited the dose to a few milligrams because of the release of free iron [18][19][20]. In 1947, chelating the iron as iron saccharide proved a major advance and was followed in 1954 by encapsulating iron in a high molecular weight iron dextran (Imferon) [21][22][23].…”

Section: Older Parenteral Iron Products and Limitationsmentioning

confidence: 99%

Update on intravenous iron choices

Larson

Coyne

2014

Current Opinion in Nephrology and Hypertension

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Section: Older Parenteral Iron Products and Limitationsmentioning

confidence: 99%

Update on intravenous iron choices

Larson

Coyne

2014

Current Opinion in Nephrology and Hypertension

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“…Although it was recognised as early as 1893 that iron supplementation was of benefit to some anaemic patients [16], deficiency of iron stores still remains probably the commonest of Int J Sports Med 1998; 19: 474-478 0 Georg Thierne Verlag Stuttgart -New York ISSN 0172-4622 all causes of anaemia [ I 1. The amount of iron stored within the body can be estimated indirectly from serum ferritin concentration, which has been found to correlate with stainable iron stores in normal populations [15].…”

Section: Introductionmentioning

confidence: 99%

The Haematological Response to an Iron Injection Amongst Female Athletes

Ashenden¹,

Fricker²,

Ryan³

et al. 1998

Int J Sports Med

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The aim of this study was to monitor the haematological response of female athletes with moderately low ferritin values to an iron injection. We measured the total haemoglobin mass of 11 female basketballers with a range of ferritin values who lived and trained together for the duration of the study (age 18+/-1, range 16-19 yrs), [Hb] 12.4+/-1.3, 11.5-16.1 g x dL; ferritin 35.6+/-15.6, 9-58 microg x L). A total dose of 2.5 mL Ferrum H was administered to six squad members who were matched with the remaining five controls based on ferritin measures obtained three weeks earlier. Venous blood samples were drawn weekly to obtain full blood counts, reticulocyte parameters as well as iron profiles. There was no change detected in any of the haematological parameters measured in the treatment group compared to controls. A repeated measures ANOVA (treatment x time) demonstrated that neither total haemoglobin mass (P = 0.91) nor [Hb] (P = 0.79) altered significantly between groups, whilst the mean haemoglobin content of reticulocytes also showed no response (P = 0.17). Because a positive haematological response is definitive evidence of impaired red cell production, our results indicate that none of the athletes were iron deficient at the time of the injection. This suggests that low ferritin values in trained female athletes are not always associated with impaired red cell production.

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“…Sydenham is thought to have first introduced iron therapy for chlorosis in 1681, 1 but it was later, in the early 19th century, that Pierre Blaud introduced ferrous sulfate in pill form. 2 Its safety and efficacy have enabled countless people to overcome the morbidity of iron deficiency anemia.…”

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confidence: 99%