The treatment of chronic osteomyelitis: A 10 year audit

Quadriceps muscle reconstruction with free functioning latissimus dorsi muscle flap after oncological resection

“…Free muscular flaps have been early introduced in clinical practice for their biological characteristics and versatility to cover wide tissue defects both post-traumatic or after oncological excision. The abundant vascularity of the muscle tissue and its plasticity explain their frequent use also for the treatment of infected tissue defects 4 and in anatomical districts with poor vascularization such as osteomyelitis, 5 diabetic ulcers, 6 radionecrosis, 7 etc. The first clinical applications of free functioning muscle flaps date back to the late seventies of the last century.…”

Panton-Valentine leukocidin osteomyelitis in children: a growing threat

“…The use of a well vascularised inter-positional muscular flap such as that from the gastrocnemius in cases of tibial infection has been advocated to allow adequate soft tissue coverage following extensive bone and soft tissue debridement. The use of muscle interposition flaps to cover debrided bony defects has previously been used in chronic osteomyelitis (Smith et al, 2006) but has also proven useful in treating acute PVL-SA osteomyelitis.…”

Usefulness of SBA-15 mesoporous ceramics as a delivery system for vancomycin, rifampicin and linezolid: a preliminary report

“…These and other circumstances have made the management of bone infection a complex process that must include different specialists and techniques. The initial disease results in inflammatory destruction, necrosis and bone neoformation, which could progress to a chronic state [1], which can be extremely difficult to treat. Different types of osteomyelitis depend on duration, infection mechanism, size of affected bone and other factors [2].…”