The Treatment of Congenital Pseudarthrosis of the Tibia with Pulsing Electromagnetic Fields

Sutcliffe, M. L.; Goldberg, A. A. J.

doi:10.1097/00003086-198206000-00008

Cited by 37 publications

(5 citation statements)

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“…These results would indicate that the change of the cellular condition from under-stimulation to off-stimulation contributes to the higher incorporation of both 3H-thymidine and 35S-sulfuric acid into the cartilage cells. In other words, the electrical change of the cell environment is the Our data support the benefit of clinical application of PEMF stimulation to bone and cartilage disorders such as ununited fractures and congenital pseudarthrosis, which have been investigated by many researchers [2,3,5,8,17,24,27]. Under these conditions, the healing process was shown to be similar to endochondral ossification in a growth plate [4].…”

Section: Discussionsupporting

confidence: 75%

Effects of pulsing electromagnetic fields on cultured cartilage cells

Sakai

Suzuki

Nakamura

et al. 1991

International Orthopaedics

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In order to evaluate the effects of pulsing electromagnetic fields (PEMFs) on cell proliferation and glycosaminoglycan (GAG) synthesis and to study the action site of PEMF stimulation in the cells, we performed a series of experiments on rabbit costal growth cartilage cells and human articular cartilage cells in culture. A PEMF stimulator was made using a Helmholz coil. Repetitive pulse burst electric currents with a burst width of 76 ms, a pulse width of 230 microseconds and 6.4 Hz were passed through this coil. The magnetic field strength reached 0.4 mT (tesla) on the average. The syntheses of DNA and GAG were measured by 3H-thymidine and 35S-sulfuric acid incorporations. The effects on the cells treated with lidocaine, adriamycin and irradiation were also measured using a colony forming assay. The PEMF stimulation for the duration of 5 days promoted both cell proliferation and GAG synthesis in growth cartilage cells and intermittent stimulation on and off alternatively every 12 h increased them most significantly, while, in articular cartilage cells, the stimulation promoted cell proliferation, but did not enhance GAG synthesis. PEMF stimulation promoted cells treated with lidocaine more significantly than with other agents. These results present evidence that intermittent PEMF stimulation is more effective on both cell proliferation and GAG synthesis of cartilage cells than continuous stimulation, and that the stimulation could exert effects not by nucleus directly, but by the cellular membrane-dependent mechanism. This study provides further basic data to encourage the clinical application of PEMF stimulation on bone and cartilage disorders.

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Section: Discussionsupporting

confidence: 75%

Effects of pulsing electromagnetic fields on cultured cartilage cells

Sakai

Suzuki

Nakamura

et al. 1991

International Orthopaedics

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“…In particular, a control study on a group of patients with congenital pseudoarthritis of tibia has shown that employment of stimulation in support of surgical intervention with endomedullar synthesis is able to limit dysmmetry of the limbs and protect the patient at risk of refracture (53)(54)(55)(56)(57)(58). Congenital pseudoarthritis has been treated with inductive and faradic systems.…”

Section: Congenital Pseudoarthritismentioning

confidence: 99%

Consensus Conference on the Use of Electrical and Magnetic Stimulation in Orthopedics and Traumatology International Symposium, Electromagnetic Fields and Bone Healing, Bologna, June 1997

Traina

Romanini

Benazzo

et al. 1998

Electro- and Magnetobiology

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“…The natural history is persistent instability and progressive deformity [1][2][3][4][5] . Treatment options have varied greatly and have included both operative and nonoperative approaches [6][7][8][9] . Although no single method has proven ideal, the highest rates of union have been reported after surgery [10][11][12][13][14][15][16] .…”

mentioning

confidence: 99%