1936
DOI: 10.1001/jama.1936.02770290022006
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The Treatment of Early Syphilis With Electropyrexia

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Cited by 16 publications
(4 citation statements)
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“…In fact, heat treatment was performed in the past with the knowledge that Treponema are susceptible to increased temperature, and in vitro studies have shown temperatures greater than 408C to be lethal to the organism. 11,13 Regarding metabolic requirements, the Treponemal spirochete is metabolically deficient, lacks an oxidative Krebs cycle, prefers low oxygen environments, and is reliant on the host enzymatic machinery for survival. 14 It is tempting to speculate about the invasive patterns of the syphilis organism during infection and why in rare instances, the spirochetes home to the follicular epithelium, as in our case.…”
Section: Case Discussionmentioning
confidence: 99%
“…In fact, heat treatment was performed in the past with the knowledge that Treponema are susceptible to increased temperature, and in vitro studies have shown temperatures greater than 408C to be lethal to the organism. 11,13 Regarding metabolic requirements, the Treponemal spirochete is metabolically deficient, lacks an oxidative Krebs cycle, prefers low oxygen environments, and is reliant on the host enzymatic machinery for survival. 14 It is tempting to speculate about the invasive patterns of the syphilis organism during infection and why in rare instances, the spirochetes home to the follicular epithelium, as in our case.…”
Section: Case Discussionmentioning
confidence: 99%
“…All patients were free from all clinical, cutaneous, and serological signs and symptoms of syphilis for 18 months. 3 Dr Lawless also established one of Chicago's most thriving clinics in the heart of the black community, located in Chicago's South Side. Despite facing racism as a student, teacher, and physician at Northwestern University, he welcomed to his office patients from diverse racial and economic backgrounds who were seeking treatment for rare skin disorders.…”
Section: Theodore Lawless-a Physician-scientist Philanthropist and Ch...mentioning
confidence: 99%
“…He noted that spirochetes that were originally found on both chancres and lymph glands disappeared after applying this technique. All patients were free from all clinical, cutaneous, and serological signs and symptoms of syphilis for 18 months …”
mentioning
confidence: 99%
“…Simpson70 advocates the use of fever therapy in the treatment of primary syphilis as well as in the later stages. In a recent article, Neymann and others 62 have discussed pertinently the value of arti¬ ficial fever by physical means. In the late stages of syphilis most of the studies have been made on the usefulness of fever therapy in the treatment of syphilis of the nervous system and in the treatment of ocular syphilis.…”
Section: Diseases Treatedmentioning
confidence: 99%