The Treatment of Fever from a Clinical Viewpoint

Dinarello, C A

doi:10.1007/978-3-642-68569-9_16

Cited by 4 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maximal normal oral temperature is 37.2 °C (98.9 °F) at 6 am and 37.7 °C (99.9 °F) at 4 pm; these values define the 99 th percentile for healthy individuals. In light of these studies, an am temperature of > 37.2 °C (> 98.9 °F) or a pm temperature of > 37.7°C (> 99.9°F) would define a fever [11], and this may be due to any sort of (that may include either epidemic or pandemic) infections affecting our body. An epidemic is a rapidly spreading viral or microbial outbreak of disease within a confined region.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, Herbo-Mineral Drug in Patients with Viral Fever

2021

Curr Res Complement Altern Med

View full text Add to dashboard Cite

A viral infection develops when an organism's body is attacked by pathogenic viruses, and infectious virus particles attach to and enter susceptible cells. There are a few antiviral medicines available to manage the viral infection. The objective of this pilot clinical study was to demonstrate the preliminary evaluation on the efficacy and safety of ZingiVir-H, a herbomineral Ayurvedic preparation in hospitalized adults diagnosed with viral infection. A total of thirty patients above 18 years of age presenting with fever were enrolled from 3 rd October 2019 to 28 th December 2019 for conducting the pre-test and post-test clinical trial. All the patients were administered with ZingiVir-H tablet (500 mg) orally every 4 th hour along with lukewarm water after light meal. The intervention was continued until the body temperature became normal. Body temperature, Complete Blood Count (CBC), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (C-RP), Liver Function Test (LFT), and Renal Function Test (RFT) were recorded after treatment, first follow-up (on 7 th day of discharge) and 2 nd follow-up (on 30 th day from first follow-up date). LFT and RFT were observed before treatment and 2 nd follow-up (on 30 th day from first follow-up date) and the results obtained were analyzed statistically. Repeated measurements with ANOVA recorded a significant decrease in body temperature (within an average of 4.3 days), CBC, ESR, C-RP after the intervention. The LFT and RFT parameters before and after treatments were within the recommended clinical range which established the hepato-renal safety of the ZingiVir-H in the study subjects. This study proved that ZingiVir-H is highly effective and safe in managing viral fever (jwara).

show abstract

Section: Introductionmentioning

confidence: 99%

A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, Herbo-Mineral Drug in Patients with Viral Fever

2021

Curr Res Complement Altern Med

View full text Add to dashboard Cite

show abstract

Antipyretische Analgetika

Brune¹

1996

Analgetika Antinozizeptiva Adjuvanzien

View full text Add to dashboard Cite

Physical versus pharmacological counter-measures

Wenzel

Werner

1988

Europ. J. Appl. Physiol.

View full text Add to dashboard Cite

128 experiments were carried out on febrile rabbits at air temperatures of 8, 18, 24 and 30 degrees C in order to analyze the thermoregulatory effects and mechanisms of physical and/or pharmacological counter-measures. Fever was achieved by injection of 0.1 micrograms Salmonella typhi endotoxin (LPS)/kg into an ear vein. As the pharmacological counter-measure, injections of acetylsalicylic acid (ASA) into an ear vein were chosen. For the physical counter-measure, cooling thermodes (5 degrees C) were constructed for the abdominal skin, for the ear and for the rectum. ASA injections had no effect on the first fever maximum, even if applied 20 to 60 min before the LPS injection, but eliminated the second fever maximum. Of course, the additional hyperthermia observed at 30 degrees C ambient temperature could not be eliminated by the injections. On the other hand, cooling procedures can obviously not affect the pyrogen-induced temperature increase, but reduce the hyperthermic effect of a higher ambient temperature. Rectal cooling was more effective than ear or abdominal skin cooling. Abdominal cooling evoked an increase in metabolic heat production. Application of combined physical and pharmacological counter-measures achieved the strongest and quickest reduction of the second maximum, whereas the first maximum was not affected, as in all other experiments. The study emphasizes the necessity of taking into account the time course of the effector mechanisms in order to discriminate between hyperthermic and febrile components of temperature increase. In the initial phase cooling measures would evoke unwanted regulatory responses of the effectors, whereas during the second febrile maximum they would achieve a quicker reduction of core temperatures.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

The Treatment of Fever from a Clinical Viewpoint

Cited by 4 publications

References 64 publications

A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, Herbo-Mineral Drug in Patients with Viral Fever

A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, Herbo-Mineral Drug in Patients with Viral Fever

Antipyretische Analgetika

Physical versus pharmacological counter-measures

Contact Info

Product

Resources

About