The treatment of ichthyosis with vitamin A

Safety of High-Dose Vitamin A

“…In fact, the majority of patients were able to sustain over a long supplementa tion period the daily dose of 300,000 IU. which was recommended by long-lasting dermatological experi ence [19][20][21][22]. As for clinical toxicity, our results are in agreement with two large reviews on acute and chron ic side effects of vitamin A supplementation [14.…”

Hypovitaminosis-A in a Family with Tylosis and Clinodactyly

“…Low levels of serum vitamin A have also been noted in ichthyosis (Rapaport et al, 1942;Peck et al, 1943a;Leitner and Moore, 1946), pityriasis rubra pilaris (Leitner and Moore, 1946;Leitner and Ford, 1947)the similarity of the latter to the lesions found in vitamin-A deficiency has been stressed by Pettler (1936) and by Sutton and Sutton (1949)-and less frequently in commoner skin diseases such as eczema and psoriasis (Marchionini and Patel, 1937). Moore (1957) differentiates between skin lesions due to " dietary " and those due to " secondary " vitamin-A deficiency.…”

“…The association between various hyperkeratotic and dyskeratotic skin diseases and hypovitaminosis-A has been noted (Rapaport et al, 1942;Peck et al, 1943aPeck et al, , 1943bLeitner and Moore, 1946;Leitner and Ford, 1947). Low blood levels of vitamin A were found in tylosis (Porter, 1951) and some improvement in the skin lesions occurred on giving high doses of the vitamin.…”

Congenital Ichthyosiform Erythrodermia Treated by Hypnosis

“…hydros. containing 10% sodium chloride (Ljungstrom, 1941), and occasional intensive courses of vitamin A by mouth in a dosage of 150,000 units daily (Rapaport, Herman, and Lehman, 1942). The former kept the skin reasonably supple, and the latter would bring about a phase of desquamation and a noticeable temporary improvement, but the condition would relapse after a fortnight or so, and for a short while afterwards the skin would be rather worse.…”