The Treatment of Intracranial Aneurysms by Injection with a Tissue Adhesive

Abstract

The authors have developed a technique of occluding intracranial aneurysms by the direct injection of a tissue adhesive. Previous work in our laboratory had revealed the unusual intravascular characteristics and physiological properties of isobutyl-2-cyanoacrylate (IBC). These findings had indicated the feasibility of utilizing IBC in the treatment of intracranial aneurysms by its direct injection. We have now treated twenty patients by this method. Eighteen aneurysms were injected during open craniotomy and two were treated by closed stereotactic injection utilizing electronic radiography. Follow-up data, ranging from 1 to 6 years after operation, are available on these patients. Sixteen patients (80% of the series) have had good to excellent results. Our experience and the application of this technique as a potential tool in the treatment of intracranial aneurysms are discussed.

Treatment of Cerebral Aneurysms—Surgical Clipping or Endovascular Coiling: The Guiding Principles

“…34 Mullan treated an aneurysm by using electrothrombosis, 35 and Sheptak treated aneurysms by injecting isobytyl-2-cyanoacrylate into the fundus of the lesion under direct visualization using a stereotactic technique. 36 The development of microcatheters and guidewires allowed safe, selective aneurysmal catheterization and allowed use of coils for treating aneurysms. In 1990, Dowd, Arnaud, and Higashida selectively embolized intracranial aneurysms using platinum coils.…”