The Treatment of Intracranial Gliomas by Surgery and Radiation

Pool, James L.; Kamrin, Robert P.

doi:10.1159/000386048

Cited by 9 publications

(3 citation statements)

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“…We agree with Pool and Kamrin (1966) that some glioblastoma patients can survive for 5 years or even longer, whether postoperative treatment is given or not. When considering the results of chemotherapy and combined treatment the shortest survival times must be looked at.…”

Section: Discussionsupporting

confidence: 76%

“…According to Fr/inkel and German (1958) 75% of glioblastoma patients treated by surgery alone die within 6 months. Taveras et al (1962) reported a 6 month mortality rate of 86~According to all recent publications better results were obtained by using postoperative radiotherapy, but the survival periods were no longer than 12-18 months.According to Pool and Kamrin (1966) death occurred within 1 year in 85% of patients treated by radiotherapy, an/[ the 6 month mortality rate was high. Death was recorded within 6 months in 25%, and within 1 year in 71~ of the 48 glioblastoma patients exposed to surgical intervention and irradiation by Uihlein et al (1966).…”

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confidence: 99%

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Combined postoperative treatment of malignant supratentorial gliomas with vincristine sulphate and radiotherapy

et al. 1973

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SummaryThe results of combined irradiation and intravenous Vineristine therapy applied to 18 malignant glioma patients after operation and reoperation are reported. Histological examination of the first 15 turnouts showed that 12 were glioblastomas and 3 malignant astroeytomas. Tumours removed by reoperation were glioblastomas.Combination therapy consisted of the immediate postoperative administration of 6-12 mg VCR (0.08-0.1 mg/kg) over an 8-14 days period followed by 2 courses of teleeobalt irradiation giving a total dose of 5,000 rads. Most patients received a second course of 8-12 mg VCt~ 6 months after surgery. The total dose of VCI% was 15-22 mg. Irreversible toxic effects were not observed.The results obtained with combination therapy were somewhat better than those achieved with radiotherapy alone. The mean survival time was 9 months. Patients lived after re-operation for at least as long as they had after a first operation. Death did not occur within a period of 6 months following surgery.Macroseopically radical tumour removal is still (3.9) the first and most importartt treatment of malignant glioma. According to Fr/inkel and German (1958) 75% of glioblastoma patients treated by surgery alone die within 6 months. Taveras et al. (1962) reported a 6 month mortality rate of 86~According to all recent publications better results were obtained by using postoperative radiotherapy, but the survival periods were no longer than 12-18 months.According to Pool and Kamrin (1966) death occurred within 1 year in 85% of patients treated by radiotherapy, an/[ the 6 month mortality rate was high. Death was recorded within 6 months in 25%, and within 1 year in 71~ of the 48 glioblastoma patients exposed to surgical intervention and irradiation by Uihlein et al. (1966).

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Section: Discussionsupporting

confidence: 76%

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confidence: 99%

Combined postoperative treatment of malignant supratentorial gliomas with vincristine sulphate and radiotherapy

et al. 1973

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“…Admite-se que adultos com astrocitoma grau III ou IV devam ser tratados com telerradioterapia e, eventualmente, com telerradioterapia complementar de reforço ou radioterapia intersticial. Esses procedimentos prolongam a sobrevida de doentes com astrocitomas anaplásicos supratentoriais, segundo estudos retrospectivos 33,38,81,126,162,166,181,182,185,186,200,213,219,224,226,227,228 e prospectivos multicêntricos recentes 223,225 . Nos doentes que se submetem à excisão radical dos astrocitomas malignos, a média de sobrevida é de 4 meses; o tempo de sobrevida aumenta para 9,25 meses naqueles tratados com telerradioterapia após a ressecção 184 .…”

Section: Gliomas Anaplásicosunclassified

Untitled

2002

Arq Bras Neurocir

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RESUMO PALAVRAS-CHAVEBraquiterapia. Radioterapia. Tumores encefálicos. ABSTRACT Interstitial radiotherapy for treatment of brain tumors IntroduçãoAs neoplasias do encéfalo estão entre a sexta e oitava causas mais freqüentes de lesões intracranianas dos adultos e a segunda causa mais comum de doença neurológica crônica em pediatria. Os tumores primários do encéfalo correspondem a 2% dos óbitos provocados pelo câncer. São responsáveis por 20% dos tumores malignos diagnosticados antes dos 15 anos de idade e por, aproximadamente, 30% das mortes na sociedade ocidental 118 .Graças à adoção de recursos tecnológicos mais apropriados, à execução de intervenções terapêuticas precoces e à adoção de tratamentos adjuvantes mais adequados, os resultados das terapias para as neoplasias encefálicas tornaram-se mais favoráveis. Entre esses recursos, destacam-se a delineação das lesões com novas técnicas de aquisição de imagem acopladas aos princípios de estereotaxia, a neuronavegação, a eletrofisiologia intra-operatória, a ressonância magnética realizada durante o ato operatório e as conquistas recentes nas áreas de quimioterapia, radioterapia, biologia molecular e genética dos tumores encefálicos.Entretanto, apesar do entusiasmo com a aplicação dos novos conhecimentos em neurooncologia -como a terapia gênica e a imunoterapia -, os procedimentos clássicos fundamentados em cirurgias radicais ou paliativas e em radioterapia e, eventualmente, em quimioterapia são ainda os melhores instrumentos para o tratamento da maioria das lesões neoplásicas primárias ou secundárias do encéfalo. Desses, os procedimentos de radioterapia são considerados um dos mais efetivos, isoladamente ou complementando tratamentos cirúrgicos ou quimioterápicos 22 .

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CCNU-chemotherapy of hemispheric supratentorial glioblastoma multiforme

Cianfriglia

Pompili

Riccio

et al. 1980

Cancer

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One hundred and three patients with hemispheric supratentorial glioblastoma multiforme were studied. All patients were operated on and a histologic diagnosis of glioblastoma multiforme was made. Patients were randomly placed in one of three treatment schedules within 3 weeks of surgery: Group A: combined radiation therapy and drug (CCNU) therapy (26 cases); Group B: CCNU given orally every 6-8 weeks (27 cases); Group C: standard radiation therapy alone (50 cases). All patients were periodically controlled by clinical and instrumental (EEG, scan, EMG, CAT) evaluations; laboratory data examinations were also frequently performed. The treatment results have been evaluated according to length of survival, social quality of life, and positive or negative response to chemotherapy. In our opinion the clinical findings are interesting but the statistical results are somewhat negative, especially when the groups of patients are not homogeneous.

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The Treatment of Intracranial Gliomas by Surgery and Radiation

Cited by 9 publications

References 0 publications

Combined postoperative treatment of malignant supratentorial gliomas with vincristine sulphate and radiotherapy

Combined postoperative treatment of malignant supratentorial gliomas with vincristine sulphate and radiotherapy

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CCNU-chemotherapy of hemispheric supratentorial glioblastoma multiforme

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