The treatment of iron overload with desferrioxamine B

Norman, Conolly

doi:10.1007/bf02953856

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Previous investigations have indicated that the thickness of the anodized oxide film was proportional to the forming potential. 7,[29][30][31][32] This relationship has been confirmed in this investigation except that two different stages were observed. At a low forming voltage, amorphous oxide was formed at a relatively higher rate per increase in forming voltage.…”

Section: Resultssupporting

confidence: 83%

Microstructure and Electrochemical Characteristics of Aluminum Anodized Film Formed in Ammonium Adipate Solution

Chang

Liao

Chen

et al. 2003

J. Electrochem. Soc.

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The morphology, chemical composition, and crystal structure of aluminum anodized films formed in 85°C aqueous ammonium adipate electrolyte at various forming voltages ͑20-200 V͒ were investigated. The relationship between the microstructure and the electrochemical behavior of the anodized oxide film was also explored. The results showed that an amorphous oxide film was formed when the forming voltage was 100 V or lower. Both the increase of film thickness per increase in voltage and the relative dielectric constant were independent of the forming voltage. When the forming voltage exceeded 100 V, crystalline ␥Ј-Al 2 O 3 was observed. The crystalline clusters first appeared at the center of the amorphous anodized oxide film and extended outward as the forming voltage increased. Two well-defined layers could be clearly recognized when the forming voltage was 200 V. The presence of crystalline ␥Ј-Al 2 O 3 was beneficial in raising the relative dielectric constant and the dielectric strength of the anodized oxide films. The relative dielectric constant ͑13.2͒ of the anodized oxide film formed at 200 V was higher than that of the film formed at a lower voltage. However, the increase of film thickness per increase in voltage was decreased. Microscopic examination revealed that crystallization induced the formation of defects which caused a decrease in the resistivity of the anodized oxide films.

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Section: Resultssupporting

confidence: 83%

Microstructure and Electrochemical Characteristics of Aluminum Anodized Film Formed in Ammonium Adipate Solution

Chang

Liao

Chen

et al. 2003

J. Electrochem. Soc.

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“…A range of structurally diverse microbial natural products contain one or more hydroxamate functional groups (figure 1), which are employed as metal ion chelators to inhibit or enable important biological processes [1]. Prominent examples include trichostatin A (2), a histone deacetylase (HDAC) inhibitor with anti-cancer activity that is widely used in epigenetics research [2], and desferrioxamine B (7), which is marketed as desferral for the treatment of iron overload and neuroblastoma in humans [3,4]. Trichostatin A blocks histone deacetylation via chelation of its hydroxamate group to the active zinc(II) ion of HDACs [5], whereas desferrioxamine B uses its three hydroxamate groups to sequester ferric iron via formation of a hexadentate complex [6].…”

Section: Introductionmentioning

confidence: 99%

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC

Ronan

Kadi

McMahon

et al. 2018

Phil. Trans. R. Soc. B

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Hydroxamate groups play key roles in the biological function of diverse natural products. Important examples include trichostatin A, which inhibits histone deacetylases via coordination of the active site zinc(II) ion with a hydroxamate group, and the desferrioxamines, which use three hydroxamate groups to chelate ferric iron. Desferrioxamine biosynthesis in species involves the DesD-catalysed condensation of various-acylated derivatives of -hydroxycadaverine with two molecules of-succinyl--hydroxycadaverine to form a range of linear and macrocyclic tris-hydroxamates. However, the mechanism for assembly of the various -acyl--hydroxycadaverine substrates of DesD from -hydroxycadaverine has until now been unclear. Here we show that the gene of encodes the acyl transferase responsible for this process. DesC catalyses the-acylation of -hydroxycadaverine with acetyl, succinyl and myristoyl-CoA, accounting for the diverse array of desferrioxamines produced by The X-ray crystal structure of DesE, the ferrioxamine lipoprotein receptor, in complex with ferrioxamine B (which is derived from two units of -succinyl--hydroxycadaverine and one of -acetyl--hydroxycadaverine) was also determined. This showed that the acetyl group of ferrioxamine B is solvent exposed, suggesting that the corresponding acyl group in longer chain congeners can protrude from the binding pocket, providing insights into their likely function. This article is part of a discussion meeting issue 'Frontiers in epigenetic chemical biology'.This article is part of a discussion meeting issue 'Frontiers in epigenetic chemical biology'.

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“…During this section we will focus mainly in how siderophores can be used or applied to treat different diseases or help to develop diagnostic tests to improve human health, among other approaches. The first and most studied aspect of siderophore biotechnology is the treatment of iron overload during transfusion due to non-hemorrhagic conditions (34,66). Desferrioxamine B, a siderophore produced by the bacteria Streptomyces pilosus, has been used in different cases of iron poisoning, or overload, confirming its biotechnological potential (17).…”

Section: Pharmacological and Medical Applicationsmentioning

confidence: 99%

Biotechnology of siderophores in high-impact scientific fields

Serrano

2017

Biomolecular Concepts

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Different aspects of bacterial and fungal siderophore biotechnological applications will be discussed. Areas of application presented include, but are not limited to agriculture, medicine, pharmacology, bioremediation, biodegradation and food industry. In agriculture-related applications, siderophores could be employed to enhance plant growth due to their uptake by rhizobia. Siderophores hindered the presence of plant pathogens in biocontrol strategies. Bioremediation studies on siderophores discuss mostly the mobilization of heavy metals and radionuclides; the emulsifying effects of siderophoreproducing microorganisms in oil-contaminated environments are also presented. The different applications found in literature based in medicine and pharmacological approaches range from iron overload to drug delivery systems and, more recently, vaccines. Additional research should be done in siderophore production and their metabolic relevance to have a deeper understanding for future biotechnological advances.

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The treatment of iron overload with desferrioxamine B

Cited by 7 publications

References 10 publications

Microstructure and Electrochemical Characteristics of Aluminum Anodized Film Formed in Ammonium Adipate Solution

Microstructure and Electrochemical Characteristics of Aluminum Anodized Film Formed in Ammonium Adipate Solution

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC

Biotechnology of siderophores in high-impact scientific fields

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