The Treatment of Kampo-Medicine for Chronic Pancreatitis

Nakata, Kensei; Hosono, Yoneichi; Hosono, Hachiro; Sakaguchi, Hiroshi; Hosono, Shiro

doi:10.3937/kampomed.36.257

Cited by 5 publications

(7 citation statements)

References 1 publication

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“…TJ‐10 is a mixture of extracts of nine Japanese herbs with different pharmacological actions (Table 3). 35–41 Overall it has been shown to have anti‐inflammatory, analgesic and immunomodulatory properties 42 . TJ‐10 has been in clinical use in Japan for human CP for several years, although the mechanism was not clearly understood 17 .…”

Section: Anti‐inflammatory and Immunomodulatory Agentsmentioning

confidence: 99%

Pancreatic stellate cells: New target in the treatment of chronic pancreatitis

Talukdar

Tandon

2007

J of Gastro and Hepatol

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Chronic pancreatitis (CP) is characterized by progressive fibrosis, pain and/or loss of exocrine and endocrine functions. Recent in vitro and in vivo experiments have proven objectively the role of activated pancreatic stellate cells (PSC) in fibrogenesis in CP. Molecular mediators shown to regulate the pathogenesis include transforming growth factor beta (TGF-b), platelet-derived growth factor (PDGF), and pro-inflammatory cytokines such as IL-1, IL-6 and TNF-a. Furthermore, molecular pathways involving mitogenactivated protein kinases (MAPK), phosphatidyl inositol 3-kinase (PI3K), Ras superfamily G proteins, serine threonine protein kinase Raf-1 and peroxisome proliferator activated receptor gamma (PPAR-g) have been elucidated. Understanding of the pathogenesis has led to identification of novel molecular targets and development of potential newer therapeutic agents. Those found to retard the progression of experimental CP and fibrosis in animal models include interferon (IFN) b and IFN-g; a Japanese herbal medicine called Saikokeishi-to (TJ-10); curcumin; PPAR-g ligand (troglitazone); antioxidants (vitamin A, vitamin E, DA 9601 and epigallocatechin-3-gallate); a protease inhibitor (camostat mesilate) and hydroxymethylglutaryl-CoA inhibitor (lovastatin). This review summarizes the current literature addressing the role of different pharmacological agents aimed at reducing or preventing inflammation and the consequent fibrogenesis in CP.

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Section: Anti‐inflammatory and Immunomodulatory Agentsmentioning

confidence: 99%

Pancreatic stellate cells: New target in the treatment of chronic pancreatitis

Talukdar

Tandon

2007

J of Gastro and Hepatol

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“…TJ-10 is a herbal medicine for CP [10,11], and as shown in table 2, is made up of a combination of Sho-saiko-to (TJ-9) and Keishi-to (TJ-45). There has been no report on the antipancreatitic effect of TJ-45.…”

Section: Discussionmentioning

confidence: 99%

“…Its effect on rat experimental CP has been reported [8,9]. Herbal medicines are also used for CP in Japan and other Asian countries [10]. A herbal medicine Saiko-keishi-to (TJ-10) has been used clinically for CP [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Herbal Medicine Keishi-To (TJ-45) and Its Components on Rat Pancreatic Acinar Cell Injuries in vivo and in vitro

Motoo

Xie

et al. 2001

Pancreatology

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“…Saiko-keishi-to (TJ-10) is a Japanese herbal derivative with anti-inflammatory, analgesic, anti-emetic and immunomodulatory properties [80] . It is a mixture of extracts from nine medicinal herbs with different pharmacological actions [81][82][83][84][85][86][87] ( table 2 ).…”

Section: Herbal Medicinesmentioning

confidence: 99%