The Treatment of Keloids at Radiumhemmet 1921--1941

Jacobsson, Folke

doi:10.1177/028418514802900217

Cited by 7 publications

(10 citation statements)

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“…Freund reported in 1898, 3 years after x-rays were first detected by Wilhelm Conrad Röntgen, that hypertrophic scars could be restored to normal skin by roentgen treatment. 1 Subsequently, in 1901, Harris reported that keloids could be treated preoperatively by roentgen exposure. Freund then, in 1909, described the first combination treatment protocol that involved surgery and postoperative roentgen treatment.…”

mentioning

confidence: 99%

“…Freund then, in 1909, described the first combination treatment protocol that involved surgery and postoperative roentgen treatment. 1 Thereafter, different radiation protocols were developed for keloid treatment. Some of these involved external irradiation using superficial [2][3][4][5][6][7][8][9][10][11] and orthovoltage [12][13][14] x-rays (photons) and ␤-rays (electron beams).…”

mentioning

confidence: 99%

“…In addition, radiation therapy has been used as a monotherapy 11,23,29 or in combination with adjuvant therapy delivered preoperatively 33 or postoperatively. [1][2][3][4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32] However, it is generally believed that keloids are best treated by a combination of surgery and postoperative radiation therapy, although it should be noted that this notion has not yet been tested by randomized controlled trials. Although it is difficult to determine the effectiveness of irradiation for the treatment of keloids because of variations between studies in patient race, age, and sex; keloid area and size; radiation source and dose; result assessment strategies; and follow-up term, the reported postoperative radiation response rates (the rate of recurrences regardless of patient satisfaction) generally fall between 67 and 98 percent.…”

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confidence: 99%

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Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis

Ogawa

Yoshitatsu

Yoshida

et al. 2009

Plastic and Reconstructive Surgery

156

118

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confidence: 99%

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Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis

Ogawa

Yoshitatsu

Yoshida

et al. 2009

Plastic and Reconstructive Surgery

156

118

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“…Harris subsequently reported preoperative roentgen exposure for the treatment of keloids in 1901. The first combination of surgery and postoperative Roentgen treatment of keloids was described by Freund in 1909 [21]. Currently, surgery combined with irradiation is an effective treatment for keloids [26].…”

Section: At Presentationmentioning

confidence: 99%

Low-Dose Irradiation and Constrained Revision for Severe, Idiopathic, Arthrofibrosis Following Total Knee Arthroplasty

Farid

Thakral

Finn

2013

The Journal of Arthroplasty

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“…Freund reported in 1898, 3 years after X-rays were first detected by Wilhelm Conrad Röntgen, that HSs could be restored to normal skin by roentgen treatment [20]. Subsequently, in 1901, Harris reported that keloids could be treated preoperatively by roentgen exposure.…”

Section: Radiotherapymentioning

confidence: 99%

An overview of the pathogenesis, prevention and treatment of keloids

Ogawa

2012

Eur Surg

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Background: Keloids are pathological scars that arise from a fibroproliferative disorder of the skin, which causes injured skin to undergo abnormal wound healing. Recent studies suggest that keloid scarring may be a "multifactorial disorder" that is driven by various genetic factors along with local mechanophysiological skin factors. Thus, it appears that keloid scarring is a hyperplastic disorder of the skin that is determined by local factors rather than being a neoplasm like benign skin tumors, which can occur all over the body. This paper presents a review of previous papers and proposes new strategies for the prevention and treatment of keloids.Methods: Review. Results: To prevent the development of keloids, it is important to remove four primary factors that hamper proper wound healing, namely an inadequately moist environment, strong mechanical forces on the wound, foreign body reactions and allergies, and infections. If these factors are allowed to influence a wound, they can cause strong and continuous inflammation that can produce noticeable and/or growing keloids. Keloids can be treated by surgical methods, including tension-reduction sutures, z-plasties, core incision methods, and flap surgery. Adjuvant therapies of surgical or non-surgical therapies include corticosteroid injection, laser therapy (dye or Nd:YAG lasers), cryotherapy, radiotherapy, antitumor/ immunosuppressive agents, stabilization/compression therapy, and make-up therapy.Conclusions: Over the last decade, many high quality studies that address keloid management and treatment have been performed. There is now sufficient evidencebased information for keloid treatment. This is likely to improve significantly as our knowledge of scar biology progresses and new agents to treat keloids are developed.

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The Treatment of Keloids at Radiumhemmet 1921--1941

Cited by 7 publications

References 0 publications

Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis

Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis

Low-Dose Irradiation and Constrained Revision for Severe, Idiopathic, Arthrofibrosis Following Total Knee Arthroplasty

An overview of the pathogenesis, prevention and treatment of keloids

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