The Treatment of Lepra Reaction In Lepromatous Leprosy

Sheskin, J

doi:10.1111/j.1365-4362.1980.tb00342.x

Cited by 121 publications

(48 citation statements)

References 9 publications

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“…Thalidomide has been applied to clinical use following the discovery of its immunomodulatory properties reported by Sheskin in the late 1960s [15]. Subsequently it has been shown to inhibit angiogenesis induced by VEGF and bFGF in a rabbit corneal micropocket assay by D'Amato and colleagues.…”

Section: Discussionmentioning

confidence: 99%

Effect of thalidomide on colorectal cancer liver metastases in CBA mice

et al. 2005

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Thalidomide caused a significant reduction in the volume of colorectal liver metastases during the late phase of tumor growth. There was however no improvement in survival. Tumor growth reduction in this model did not appear to be due to microvascular changes or altered expression of VGEF or basic FGF. Further investigation into potential mechanisms of action of thalidomide and its synergistic use with other therapies is required.

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Section: Discussionmentioning

confidence: 99%

Effect of thalidomide on colorectal cancer liver metastases in CBA mice

et al. 2005

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“…His findings were confirmed by other reports [14][15][16] and by his follow-up study. 17 Recently, thalidomide therapy has been approved by the Food and Drug Administration for the treatment of erythema nodosum leprosum. However, it remains an experimental treatment for a variety of inflammatory skin disorders.…”

Section: Discussionmentioning

confidence: 99%

American Experience With Low-Dose Thalidomide Therapy for Severe Cutaneous Lupus Erythematosus

Duong¹,

Spigel²,

Moxley³

et al. 1999

Arch Dermatol

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“…There are no reliable laboratory tests to evaluate regression of the underlying immunologic phenomena. Thalidomide is remarkably effective in the treatment of T2R 88 ; it was this single benefit of thalidomide that kept the drug from being totally banned from all formularies for nearly 20 years, until newer uses for it were recognized. Medically, thalidomide is the drug of choice for T2R.…”

Section: Systemic Associationsmentioning

confidence: 99%