The Treatment of Meningococcic Meningitis With Sulfanilamide

Schwentker, Francis F.

doi:10.1001/jama.1984.03340300080035

Cited by 18 publications

(15 citation statements)

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“…The use of serum therapy fell by the wayside in the 1930s with the advent of sulfonamide therapy for treatment of meningococcal infection (318,319). In a report from the Surgeon General in 1930, rates of meningococcal meningitis were reported for the United States, with rates that are much higher than those of today (386).…”

Section: Historymentioning

confidence: 99%

Prospects for Vaccine Prevention of Meningococcal Infection

2006

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SUMMARY Neisseria meningitidis is the leading cause of bacterial meningitis in the United States and worldwide. A serogroup A/C/W-135/Y polysaccharide meningococcal vaccine has been licensed in the United States since 1981 but has not been used universally outside of the military. On 14 January 2005, a polysaccharide conjugate vaccine that covers meningococcal serogroups A, C, W-135, and Y was licensed in the United States for 11- to 55-year-olds and is now recommended for the routine immunization of adolescents and other high-risk groups. This review covers the changing epidemiology of meningococcal disease in the United States, issues related to vaccine prevention, and recommendations on the use of the new vaccine.

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Section: Historymentioning

confidence: 99%

Prospects for Vaccine Prevention of Meningococcal Infection

2006

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“…Os anos endêmicos apresentam taxas de incidência e mortalidade semelhantes ao longo do período. Assim, a tendência secular da incidência e da mortalidade, durante o sé-culo XX, poderia ser descrita como uma linha reta marcada por oscilações desprezíveis durante os períodos endêmicos, interrompida periodicamente pela ocorrência epidêmica em momentos críticos para a população (Tabela 1; Figura 1 4 . A redução da letalidade para 9,0% comparada à letalidade de 22,0% observada nos pacientes tratados com soro, levou à rápida adoção do novo tratamento no mundo todo, tão logo houve disponibilidade de sulfonamidas 5 .…”

Section: Tendência Secularunclassified

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

Moraes

Barata

2005

Cad. Saúde Pública

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“…78 In the 1950s and 1960s, sulfonamide resistance necessitated a switch to penicillin or chloramphenicol. Since the 1980s, decreased penicillin susceptibility (MIC, >0.25 mg/L) has been reported in several countries (Spain, Greece, Switzerland, Romania, France, Belgium, United Kingdom, Malawi, South Africa, Canada and the United States).…”

Section: Antimicrobial Susceptibilitymentioning

confidence: 99%

“…33 Most of the relatively resistant meningococci have belonged to either serogroup B or C. Decreased sensitivity to penicillin is caused by a reduced affinity to penicillin binding protein type 2 (PBP2) and PBP3. 76,78 The altered PBP2 found in N. meningitidids strains may have arosen from recombination processes that resulted in replacement of sequences in the native meningococcal penA gene with corresponding genetic sequences from commensal Neisseria species. Although, the clinical significance of diminished penicillin susceptibility in N. meningitidis is unclear at present both treatment failures and higher rates of complications have been observed.…”

Section: Antimicrobial Susceptibilitymentioning

confidence: 99%

Meningococcal disease: History, epidemiology, pathogenesis, clinical manifestations, diagnosis, antimicrobial susceptibility and prevention

Manchanda¹,

Gupta²,

Bhalla³

2006

Indian J Med Microbiol

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Meningoccocal disease has repeatedly caused outbreaks worldwide. There has been sudden surge of cases of meningococcemia and meningococcal meningitis in early 2005 in Delhi, India and neighboring states of Uttar Pradesh and Haryana. As of June 17, 2005, 429 probable cases of meningococcal disease have been reported in Delhi out of which 128 cases have revealed microbiological evidence of Neisseria meningitidis. It is possible that the number of cases was in excess of the numbers notified. During this episode drug susceptibility testing by MIC method (E-test) using break points recently recommended by NCCLS/CLSI, revealed that all isolates were sensitive to penicillin, ampicillin, rifampicin and ceftriaxone. As regards to ciprofloxacin, about two third of the isolates tested were found to be 'nonsusceptible' (MIC =0.03µg/mL-0.190µg/mL). All the isolates were found resistant to cotrimoxazole (MIC> 16µg/mL). Repeated outbreaks, decreased susceptibility to ciprofloxacin, which is commonly used for chemoprophylaxis of meningococcal disease, highlights the need for a constant surveillance system. Present review deals with various aspects of Neisseria meningitidis and meningococcal disease in view of recent episode.

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The Treatment of Meningococcic Meningitis With Sulfanilamide

Cited by 18 publications

References 0 publications

Prospects for Vaccine Prevention of Meningococcal Infection

Prospects for Vaccine Prevention of Meningococcal Infection

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

Meningococcal disease: History, epidemiology, pathogenesis, clinical manifestations, diagnosis, antimicrobial susceptibility and prevention

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