The Treatment of Multidrug-Resistant Tuberculosis in Turkey

Tahaoğlu, Kemal; Törün, Tülay; Sevim, Tülin; Ataç, Güliz; Kir, Altan; Karasulu, Levent; Özmen, İpek; N, Kapakli

doi:10.1056/nejm200107193450303

Cited by 208 publications

(160 citation statements)

References 7 publications

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“…Treatment of MDR-TB is difficult and drugs used for treatment are less potent, more toxic and more expensive than first line drugs [8] [9].…”

Section: Discussionmentioning

confidence: 99%

Drug Resistance Trends and Patterns of Mycobacterium Tuberculosis Isolates from Pulmonary Tuberculosis Patients at a Tertiary Care Hospital in Turkey

Yazar¹,

Yıldız²,

Günlüoğlu³

et al. 2014

JTR

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Background: We aim to determine the proportions and patterns of resistance to first-line drugs: isoniazid (H), rifampicin (R), ethambutol (E) and streptomycin (S) among pulmonary tuberculosis patients. Methods: Strains were obtained from 1584 culture positive pulmonary tuberculosis patients. All specimens were inoculated into Löwenstein-Jensen media (LJ) and TK selective; drug susceptibility tests (DST) were performed for first-line drugs. Results: Multidrug resistant (MDR) were detected in 146 (9.2%) isolates. Three hundred (18.9%) isolates were resistant to H; 220 (13.9%) to R; 168 (10.6%) to S; 137 (8.6%) to E. Any drug resistance was detected in 442 (27.9%) isolates. MDR rate was higher in male patients than females (P = 0.006). MDR rates were different according to the age groups (P = 0.02). The highest rate was in 35 -44 years and the lowest rate was in 15 -24 years. Conclusions: We found an association between middle age and male gender and MDR tuberculosis.

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“…Treatment of MDR-TB is difficult and drugs used for treatment are less potent, more toxic and more expensive than first line drugs [8] [9].…”

Section: Discussionmentioning

confidence: 99%

Drug Resistance Trends and Patterns of Mycobacterium Tuberculosis Isolates from Pulmonary Tuberculosis Patients at a Tertiary Care Hospital in Turkey

Yazar¹,

Yıldız²,

Günlüoğlu³

et al. 2014

JTR

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“…For only two, 6,7 it was not possible to obtain a response from the contacted authors to confirm that diagnosis was quality assured.…”

Section: Methodsmentioning

confidence: 99%

A Systematic Review of the Effectiveness of Hospital- and Ambulatory-Based Management of Multidrug-Resistant Tuberculosis

Bassili¹,

Fitzpatrick²,

Qadeer³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. A systematic review of the literature was conducted on the effectiveness of MDR-TB management. A metaanalysis of treatment outcomes of patients treated in hospitals versus ambulatory-based models was performed in accordance with PRISMA guidelines. The pooled treatment success rate was 66.4% (95% confidence interval [CI] 61.4-71.1%), with no statistical difference between ambulatory (65.5%; 55.1-74.6%) and hospital-based models (66.7%; 61.0-72.0%). The pooled death rate was 10.4% (6.3-16.5%), the pooled treatment failure rate was 9.5% (7.3-12.4%), and the defaulter rate was 14.3% (10.5-19.1%). None of the differences between the two models were statistically significant for any of the outcomes considered. This work improves the quality of the evidence available supporting the World Health Organizations (WHO) recommendation that patients be treated using mainly ambulatory care, conditional on infection control measures in the home and clinic, clinical condition of the patient, availability of treatment support to facilitate adherence to treatment, and provisions for backup facility to manage patients who need inpatient treatment care. BACKGROUND

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“…15 As observed earlier the radiological extent also did not affect the outcome, probably because majority of the patients had radiological extensive disease at presentation. 14,16 Cure rates were high with patient's bacilli showing resistance to both drugs rifampicin and isoniazid, patients who received ATT form RNTCP source.…”

mentioning

confidence: 54%

A study on outcome of standardized treatment in multi-drug resistance tuberculosis patients

Neeta¹,

Prashanth²,

Ramaprasad³

et al. 2016

Int J Community Med Public Health

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The Treatment of Multidrug-Resistant Tuberculosis in Turkey

Abstract: Most patients with multidrug-resistant tuberculosis can be cured with the use of appropriate, intensive treatment regimens.

Cited by 208 publications

References 7 publications

Drug Resistance Trends and Patterns of Mycobacterium Tuberculosis Isolates from Pulmonary Tuberculosis Patients at a Tertiary Care Hospital in Turkey

Drug Resistance Trends and Patterns of Mycobacterium Tuberculosis Isolates from Pulmonary Tuberculosis Patients at a Tertiary Care Hospital in Turkey

A Systematic Review of the Effectiveness of Hospital- and Ambulatory-Based Management of Multidrug-Resistant Tuberculosis

A study on outcome of standardized treatment in multi-drug resistance tuberculosis patients

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