The treatment of plantar warts with a keratolytic agent and occlusion

Veien, Niels K.; Madsen, Søren Munk; Avrach, W.W.; Hammershøy, Ole; Lindskov, R; Niordson, Ann-Marie; Stahl, Dorrit

doi:10.3109/09546639109086776

Cited by 24 publications

(13 citation statements)

References 7 publications

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“…A study looking at the effect of occlusion found a benefit when using a 17% SA gel with lactic acid. 8 Qualitative research has shown that expectation of cure from SA paints is low, and patients find the treatment difficult due to irritation of the surrounding skin. Compliance with treatments is thought to be poor.…”

Section: Destructive Treatmentsmentioning

confidence: 99%

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

et al. 2014

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Section: Destructive Treatmentsmentioning

confidence: 99%

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

et al. 2014

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“…In contrast to previous reviews, we set out to extract and analyse data using ITT principles wherever possible, as this methodology is the highest quality form of analysis that can be undertaken. Our search results yielded 77 relevant studies as outlined below 9–80 …”

mentioning

confidence: 99%

Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials

Kwok

Holland

Gibbs

2011

British Journal of Dermatology

107

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Many topical treatments for cutaneous warts exist and previous reviews of trials did not follow intention-to-treat (ITT) principles for analysis. We aimed to perform a meta-analysis and pooled analysis of randomized controlled trials (RCTs) of topical treatment for cutaneous warts using ITT principles. Systematic electronic searches (Cochrane library, Medline, Embase, Clinical trial registers) were conducted in May 2009. Included trials reported completed cure of warts and data were extracted from these trials. We performed random-effects meta-analysis and assessed heterogeneity using the I(2) statistic and conducted a pooled analysis of each treatment. We found 77 relevant studies of which the majority were of low methodological quality. Salicylic acid (SA) was superior to placebo with a risk ratio (RR) for cure of 1·60 [95% confidence interval (CI) 1·15-2·24]. Cryotherapy was not statistically better than placebo, RR 0·89 (95% CI 0·27-2·92), but aggressive cryotherapy was significantly better than gentle cryotherapy with a RR of 2·06 (95% 1·20-3·52). Combined therapy of SA and cryotherapy had a higher cure rate than either SA or cryotherapy alone. The results of the pooled analysis found a cure rate of 23% (5-73%) in placebo trials, 52% (0-87%) in SA trials, 49% (0-69%) in cryotherapy trials, 54% (45-75%) in aggressive cryotherapy trials and 58% (38-78%) in the combined cryotherapy and SA trials. Aside from the use of SA and aggressive cryotherapy there is insufficient evidence from RCTs to support the use of other therapies. Higher quality evidence is needed to evaluate other therapies.

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“…Destructive therapies consist of salicylic acids, cryotherapy, thermocautery/curettage and cautery, chemical cautery, carbon dioxide laser, pulsed dye laser, and photodynamic therapy [3,7,13,15,24,25,26,28,29]. Virucidal methods consist of formaldehyde and gluteraldehyde [11].…”

Section: Discussionmentioning

confidence: 99%

“…There is no single treatment that is 100% effective, and different types of therapy may be combined. The appropriate treatment option depends on a variety of factors (including the age of the patient, location of the lesion, past treatment, etc) and includes a variety of acids, podophyllin, podophyllotoxin, chemotherapeutic agents, retinoids, topical sensitizers, a spectrum of surgical techniques, and cryotherapy [1,2,3,6,7,8,9,11,12,13,14,15,16,21,22,23,24,25,26,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

Treatment of common warts with surgery and systemic isotretinoin

et al. 2002

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Warts, or verrucae, are benign epithelial proliferations of the skin and mucosa caused by infection with human papilloma viruses. These are slow-growing lesions that can remain subclinical for long periods of time. Since there is no single treatment that is 100% effective, and the lesions may effect the patient's life quality, combinations of treatment modalities may be used. A case of hornlike warts on both hands and all over the body is presented. He was treated with surgical excisions and systemic isotretinoin at a dose of 1 mg/day administered for 6 months. The warts were largely resolved by the 6th postoperative month.

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The treatment of plantar warts with a keratolytic agent and occlusion

Cited by 24 publications

References 7 publications

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials

Treatment of common warts with surgery and systemic isotretinoin

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