The Treatment of Pneumococcic Meningitis With Penicillin

Pneumococcic Meningitis in Infants and Children

“…One patient recovered without the use of intrathecal medication, and a second had only negligible amounts intrathecally; three others had only one intrathecal in¬ jection. 4. Recovery of an infant 4 weeks of age is reported, the seventh newborn infant reported in the literature as recovering after pneumococcic meningitis.…”

Activity of a New Antimalarial Agent, Pentaquine (Sn 13,276)

“…of quinine a day in divided doses for fourteen days is equal in toxicity to 30 to 45 mg. of pamaquine base administered similarly with quinine. At this dosage, the toxic symptoms are occasional ano¬ rexia, abdominal discomfort or pain and slight methe¬ moglobinemia (average for 44 patients, 4.5 per cent). In limited therapeutic studies of the drug at higher dosages (120 mg. base per day) the toxicity has been considerably greater than that observed with 60 mg. of pamaquine, possibly equal to the toxicity of 90 mg. of pamaquine base.…”

Otogenous Intracranial Complications

“…But opinions differ regarding the use of therapy intrathecally. Sweet and others 15 and Siegal1<! and others have reported neurogenic bladder disturbances, transverse myelopathy, paraplegia, convulsions, and persistent headache after penicillin intrathecally.…”