The Treatment of Primary Breast Cancer in Older Women With Adjuvant Therapy

Peters, Elke E.M.; Anzeneder, Tobias; Jackisch, Christian; Dimpfl, T.; Kunz, G.; Katalinic, Alexander; Waldmann, Annika

doi:10.3238/arztebl.2015.0577

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…At the same time, DFS was significantly shorter in the group of older women. Several retrospective studies investigating the use of adjuvant chemotherapy in elderly patients have reported different treatment rates in the range from 5 to 32 % (Vlastos et al 2001;Woodard et al 2003;Brunello et al 2005;Hawfield et al 2006;Peters et al 2015). However, these studies are not readily comparable due to differences in age distributions and patient characteristics.…”

Section: Discussionmentioning

confidence: 87%

Adjuvant chemotherapy in elderly patients with primary breast cancer: are women ≥65 undertreated?

Wallwiener

Hartkopf

Grabe

et al. 2016

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 87%

Adjuvant chemotherapy in elderly patients with primary breast cancer: are women ≥65 undertreated?

Wallwiener

Hartkopf

Grabe

et al. 2016

J Cancer Res Clin Oncol

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“…P values of < 0.05 were considered to indicate statistical significance. Given the risk of α- error from many statistical analyses, we additionally adjusted Bonferroni's correction for the P values as reported [ 15 ]. P values of < 0.0042 were considered to indicate statistical significance after Bonferroni's correction, as 12 individual tests were performed (0.05/12).…”

Section: Methodsmentioning

confidence: 99%

Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage

et al. 2018

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We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition.

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“…Age affects the type of surgery. This is especially true for breast-conserving surgery, which is offered less often to older patients [32, 33]. Not only specialists but also patients opt for more aggressive interventions.…”

Section: Surgerymentioning

confidence: 99%

“…A positive axillary lymph node status results in an increased use of radiation [37, 47]. An advancing age and increased comorbidity have the opposite effect [33-35, 47-51]. It is estimated that only two thirds of patients aged 71—80 years, with an indication for RT, actually receive it [51].…”

Section: Radiation Therapymentioning

confidence: 99%

Adjuvant Treatment of Elderly Breast Cancer Patients: Offer the Best Chances of Cure

et al. 2021

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Background: Breast cancer remains the most common cancer in women and a leading cause of death. Elderly people have a higher incidence of breast cancer since it increases with age. Furthermore, the extended life expectancy and advances in imaging techniques have led to an increased number of cases. Guidelines concerning the management of this specific age group are rare, mainly due to underrepresentation of seniors in clinical trials. Moreover, increased frailty, comorbidities, and a poor performance status make it complex to determine the best therapeutic approach. Summary: In this review, we attempt to summarize the current literature and aim to provide specific approaches and recommendations for prompt diagnosis, treatment, and management of breast cancer in the elderly. Key Messages: The establishment of applicable protocols is imperative and efforts are being made in this direction. A careful geriatric assessment and adequate consultation should be the standard of care and patient’s preferences should always be considered.

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The Treatment of Primary Breast Cancer in Older Women With Adjuvant Therapy

Abstract: The cause of these age-related differences is unclear. It cannot be determined from these data whether concomitant disease, the older patients' individual decisions, or other factors were responsible for their not receiving treatment as often as the younger patients did.

Cited by 15 publications

References 37 publications

Adjuvant chemotherapy in elderly patients with primary breast cancer: are women ≥65 undertreated?

Adjuvant chemotherapy in elderly patients with primary breast cancer: are women ≥65 undertreated?

Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage

Adjuvant Treatment of Elderly Breast Cancer Patients: Offer the Best Chances of Cure

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