The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms

You, Baiyang; Dun, Yaoshan; Fu, Siqian; Qi, Dake; Zhang, Wenliang; Liu, Yuan; Qiu, Ling; Xie, Murong; Liu, Suixin

doi:10.3389/fphar.2021.646489

Cited by 12 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, chronic R. rosea supplementation significantly improved exhaustive swimming-induced fatigue by increasing glycogen content, the energy supply of lipogenic enzyme expressions and protective defense mechanisms [40]. In obese mice fed a high-fat diet, Rhodiola supplementation prevented muscle atrophy and dysfunction and activated the Sirtuin1 pathway, while atrogenes were suppressed and mitochondrial quality control was improved [41]. Finally, other studies have shown that R. rosea enhances cell regeneration and energy metabolism by increasing the synthesis of adenosine triphosphate, ribonucleic acid, protein, and amino acids [42].…”

Section: Effects On Physical Strength and Endurancementioning

confidence: 97%

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

Stojcheva¹,

Quintela²

2022

Molecules

View full text Add to dashboard Cite

Rhodiola rosea L. has a long history of use in traditional medicine to stimulate the nervous system, treat stress-induced fatigue and depression, enhance physical performance and work productivity and treat gastrointestinal ailments and impotence. Apart from its well-established traditional use, a significant number of publications on the clinical efficacy of various R. rosea preparations can be found in the literature. The majority of these studies are related to the efficacy of R. rosea in terms of cognitive functions and mental performance, including various symptoms of life-stress, fatigue and burnout. The beneficial effects of this medicinal plant on enhancing physical performance have also been evaluated in professional athletes and non-trained individuals. Moreover, even though most evidence originates from pre-clinical trials, several clinical studies have additionally demonstrated the remediating effects of R. rosea on cardiovascular and reproductive health by addressing non-specific stress damage and reversing or healing the disrupted physiologies and disfunctions. Overall, in accordance with its aim, the results presented in this review provide an encouraging basis for the clinical efficacy of R. rosea preparations in managing various aspects of stress-induced conditions.

show abstract

Section: Effects On Physical Strength and Endurancementioning

confidence: 97%

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

Stojcheva¹,

Quintela²

2022

Molecules

View full text Add to dashboard Cite

show abstract

“…SIRT1 has been reported to belong to the sirtuin family, resist metabolic disorders, cancer, and cardiac stress ( Cantó and Auwerx, 2012 ) and block the muscle-specific UPS proteins MAFbx and MuRF-1 ( Lee and Goldberg, 2013 ). Activation of SIRT1 might be beneficial for sarcopenic obesity ( Guo et al, 2021 ; You et al, 2021 ), malnutrition ( Hirabayashi et al, 2021 ) and glucocorticoid-induced atrophy. Our analysis revealed that the AMPK signaling pathway was activated by PF treatment, further revealing that SIRT1 and PGC-1α, located downstream of AMPK signaling pathway, were also upregulated in CKD muscles.…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

Huang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy. The aim of this study was to explore the effects and mechanisms of paeoniflorin on CKD skeletal muscle atrophy. We demonstrated that paeoniflorin significantly improved renal function, calcium/phosphorus disorders, nutrition index and skeletal muscle atrophy in the 5/6 nephrectomized model rats. Paeoniflorin ameliorated the expression of proteins associated with muscle atrophy and muscle differentiation, including muscle atrophy F-box (MAFbx/atrogin-1), muscle RING finger 1 (MuRF1), MyoD and myogenin (MyoG). In addition, paeoniflorin modulated redox homeostasis by increasing antioxidant activity and suppressing excessive accumulation of reactive oxygen species (ROS). Paeoniflorin alleviated mitochondrial dysfunction by increasing the activities of electron transport chain complexes and mitochondrial membrane potential. Furthermore, paeoniflorin also regulates mitochondrial dynamics. Importantly, paeoniflorin upregulated the expression of silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), and phosphorylation of AMP-activated protein kinase (AMPK). Similar results were observed in C2C12 myoblasts treated with TNF-α and paeoniflorin. Notably, these beneficial effects of paeoniflorin on muscle atrophy were abolished by inhibiting AMPK and SIRT1 and knocking down PGC-1α. Taken together, this study showed for the first time that paeoniflorin has great therapeutic potential for CKD skeletal muscle atrophy through AMPK/SIRT1/PGC-1α-mediated oxidative stress and mitochondrial dysfunction.

show abstract

“…The extract complied with The Chinese Pharmacopeia 2015 (inspection report number C1051612067). The extraction method and the HPLC–MS analysis were described previously 31 . Briefly, the root of R.sacra was decocted twice for 1.5 h and 1 h respectively.…”

Section: Methodsmentioning

confidence: 99%

“…After the 8-week intervention, forced weight-loaded swimming was performed as an exhaustive exercise (EE) test to assess cardiac anti-stress capacity 5 , 31 . Briefly, mice were forced to swim with a lead sheath of 5% of body weight till exhaustion, defined as the failure to rise above the surface of the water for 7 s.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice

You

Cheng

Dun

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Myocardial injury reduction and recovery under acute cardiac stress are adversely impacted by insulin resistance (IR). We previously demonstrated that Rhodiola improved cardiac anti-stress capacity in mice. Thus, this study focuses on the preventive efficacy of Rhodiola on exhaustive exercise (EE)-induced myocardial injury of IR mice. An 8-week high-fat diet (HFD) model of IR mice was established. Rhodiola was administrated by garaging. After the 8-week intervention, half of the mice performed EE to simulate acute cardiac stress, and determine myocardial injury; The remaining mice were sacrificed following fasting to assess metabolic disorder. We found myocardial injury induced by EE in IR mice was worse and was alleviated by Rhodiola pre-conditioning. Further, the nuclear factor erythroid 2-related factor 2 (Nrf2)-related antioxidant system was impaired by HFD, while mitochondrial dynamic fusion and fission were activated by HFD as a physiological protective compensation. The Rhodiola administration rescued Nrf2 impairment and further facilitated mitochondrial fusion and fission. All these results indicate that Rhodiola is a potential treatment for the prevention of cardiac events in type 2 diabetes mellitus and metabolic syndrome patients, and the Nrf2-related antioxidant activity and mitochondrial dynamics are the proposed mechanisms.

show abstract

The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms

Cited by 12 publications

References 35 publications

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice

Contact Info

Product

Resources

About