The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

El‐Mofty, Abdel Monem

doi:10.1111/j.1365-2133.1964.tb14475.x

Cited by 13 publications

(14 citation statements)

References 14 publications

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“…The Dopa-negative reaction from the centre of the depigmented skin is consistent with vitiligo [8], and the granular deposit of IgA along the base ment membrane [9] and the HLA B8, Dw3 [10] are diagnostic for DH. Both diseases have been associated with autoimmune disorders.…”

Section: Discussionmentioning

confidence: 91%

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Dermatitis herpetiformis and Vitiligo

Ølholm-Larsen¹,

Kavli²

1980

Dermatology

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Section: Discussionmentioning

confidence: 91%

“…The regions of predilection are almost the same for both diseases [8,13], Vitiligo is known to show isomorphic reactions to epidermal-dermal trauma [14] and has in this way been described in psoriasis and lichen planus [8], In DH, the destruction in the epidermis and dermis should be sufficient to evoke an isomorphic reaction.…”

Section: Discussionmentioning

confidence: 99%

Dermatitis herpetiformis and Vitiligo

Ølholm-Larsen¹,

Kavli²

1980

Dermatology

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“…However, when irradiated with LWUV they become activated and form strong covalent bonds with DNA, forming a stable complex which stops the activity of the DNA in the cell [Musajo, et a l, 1965], Psoralens are at present used in the treatment of vitiligo and psoriasis. The rationale of their use in vitiligo is that in many cases repigmentation of leukodermic areas occurs [El Mofty, 1968]. The precise mechanism is not fully understood [Carter et al, 1974].…”

Section: Introductionmentioning

confidence: 99%

Histology of the Retina and Choroid in Ducklings Photosensitized by Feeding Ammi majus Seeds

et al. 1976

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Ducklings were photosensitized by the force-feeding of Ammi majus seeds for 5 days and exposure to sunlight. In birds sacrificed 2 weeks later, acute signs consisted of moderate vacuolization of ganglion cells. In birds sacrificed 3 ½ and 5 ½ months later, long-term effects of photosensitization included pigmentary retinopathy and hyperplasia of the retinal pigment epithelium. At the extreme periphery of the choroid, congestion and dilatation of the vessels, and transudation were observed. The probable mechanism whereby the photosensitization induces these changes in the retina and choroid of these ducklings is discussed.

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“…4), isolated from the fruits of Ammi majus and A. visnaga, respectively, are structurally isomeric, the photochemotherapy of vitiligo is restricted only to the use of psoralens [1][2][3]. With this in mind it is deemed interesting to investigate the clinical profile of khellin in the treatment of this skin disease.…”

mentioning

confidence: 99%

An Approach to the Treatment of Vitiligo by Khellin

et al. 1982

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An anticipated effect of khellin, related to its chemical structure, in the photochemotherapy of amelanosis has been investigated. In a double-blind clinical study, khellin has been orally administered to 30 vitiligo patients for 4 months with subsequent exposure to natural sunlight. At the end of the trial period. 5 patients out of 30 (16.6%) repigmented 90–100%; 7 cases (23.3%) repigmented 50–60% of the vitiliginous areas treated; 11 (36.6%) repigmented 25% or less, and 7 subjects (23.3%) showed negative response. 30 control subjects failed to repigment at all. The achieved repigmentation was stable after drug cessation for a period of 1 year. These data add a previously unreported effect for the non-psoralen compound, khellin, in the therapy of vitiligo.

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The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

Cited by 13 publications

References 14 publications

Dermatitis herpetiformis and Vitiligo

Dermatitis herpetiformis and Vitiligo

Histology of the Retina and Choroid in Ducklings Photosensitized by Feeding Ammi majus Seeds

An Approach to the Treatment of Vitiligo by Khellin

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