2019
DOI: 10.1111/aos.14048
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The treatment outcomes in IgG4‐related orbital disease: a systematic review of the literature

Abstract: IgG4‐related disease (IgG4‐RD) is an immune‐mediated systemic fibro inflammatory disease. Treatment of IgG4‐related orbital disease (IgG4‐ROD) is often indicated to relieve the symptoms and to prevent complications. For IgG4‐ROD, no international formal treatment guidelines are available and the optimal treatment strategy is uncertain. In this systematic review, we describe the efficacy of conventional and biologic disease‐modifying antirheumatic drugs (DMARDs) in IgG4‐ROD. A systematic search of Embase, Medli… Show more

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Cited by 44 publications
(45 citation statements)
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References 76 publications
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“…with type 1 AIP hypophysitis [107] skull and vertebral lesions [108][109][110] dacryoadenitis [103] neurosensory hearing loss [4] orbital lesions [109] sialoadenitis [103] chronic thyroiditis [4] meningitis [111] hilar lymphadenopathy [88] inflammatory pseudotumors esophagitis [112] interstitial pneumonitis [104] breast [113] sclerosing mesenteritis [114,115] sclerosing cholangitis [21,35,54] lung [116,117] Rosai-Dorfman disease [118,119] retroperitoneal fibrosis [105] liver [35,36,104,120] gastroenteritis [121] tubulointerstitial nephritis [106] gastric ulcer [4] vasculitis [122] swelling of the papilla of Vater [123] neuropathy [124] with type 2 AIP hepatopathy [35] myopathy [125] inflammatory bowel diseases [2,4,12,14] (ulcerative colitis and Crohn's disease)…”
Section: Possible Association With Igg4-related Lesionmentioning
confidence: 99%
“…with type 1 AIP hypophysitis [107] skull and vertebral lesions [108][109][110] dacryoadenitis [103] neurosensory hearing loss [4] orbital lesions [109] sialoadenitis [103] chronic thyroiditis [4] meningitis [111] hilar lymphadenopathy [88] inflammatory pseudotumors esophagitis [112] interstitial pneumonitis [104] breast [113] sclerosing mesenteritis [114,115] sclerosing cholangitis [21,35,54] lung [116,117] Rosai-Dorfman disease [118,119] retroperitoneal fibrosis [105] liver [35,36,104,120] gastroenteritis [121] tubulointerstitial nephritis [106] gastric ulcer [4] vasculitis [122] swelling of the papilla of Vater [123] neuropathy [124] with type 2 AIP hepatopathy [35] myopathy [125] inflammatory bowel diseases [2,4,12,14] (ulcerative colitis and Crohn's disease)…”
Section: Possible Association With Igg4-related Lesionmentioning
confidence: 99%
“…OL is malignant and needs radiotherapy, chemotherapy and/or operation [4,7,8]. IgG4-ROD is benign and approximately 90% of patients respond well to steroid treatment [5]. Both of malignant OL and benign IgG4-ROD are lymphoplasmacytic infiltrated mass-like lesions, which make clinicians difficult to differentiate from each other [6].…”
Section: Discussionmentioning
confidence: 99%
“…Multiple or multicompartmental orbital masses include venolymphatic malformations (VLM), rhabdomyosarcoma (RMS), plexiform neurofibroma, thyroid ophthalmopathy (TO), orbital pseudotumor (OP), lymphoma, metastases and IgG4-ROD [18]. The first three types of masses are common among children; the last five, among adults [3,5,18]. VLM usually appears poorly defined, lobulated and multiloculated lesions with various signal intensity on T1WI and T2WI [18].…”
Section: Discussionmentioning
confidence: 99%
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