The triglyceride-glucose index, an insulin resistance marker in newborns?

Gesteiro, Eva; Bastida, Sara; Barrios, Laura; Sánchez‐Muniz, Francisco J.

doi:10.1007/s00431-018-3088-z

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…Insulin resistance plays a crucial role in the pathogenesis of the metabolic syndrome, a significant cardiovascular disease risk factor, by causing reduced glucose metabolism, impaired insulin action, and changes in hepatic lipid metabolism. The TyG index can be used to inexpensively test insulin resistance in clinical settings [6,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Although the reasons for no-reflow creation are debatable, a number of studies have linked it to coronary artery spasm, atherosclerotic plaque embolization, and severe abnormalities of glucose metabolism [3][4][5]. Many investigations have shown that the triglyceride/glucose (TyG) index is a new measure of insulin resistance and is also connected with coronary atherosclerosis, glucose and lipid metabolism problems, and microvascular endothelial dysfunction [6][7][8][9][10]. The establishment of the "no-reflow" syndrome after PCI is also facilitated by these pathologic pathways.…”

Section: Introductionmentioning

confidence: 99%

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No-reflow phenomenon and triglyceride-glucose index in acute myocardial infarction

Kerkutluoglu,

Celik,

Dagli

et al. 2023

J CLIN MED KAZ

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Objective: The objective of this research was to evaluate the association between the measured triglyceride/glucose index (TyG) and the occurrence of no-reflow phenomena in patients with acute ST-elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI). Material and methods: This study comprised 242 patients who were treated with primary PCI for acute STEMI. The values of triglycerides and glucose at the time of admission were derived from the patient's file. Using coronary angiography records, the grade of post-procedural thrombolysis in myocardial infarction (TIMI) flow was determined. Results: After PCI, patients were divided into two groups based on their TIMI flow grade: the normal coronary flow group (n=202) and the reduced coronary flow (no-reflow) group (n=40). The group with no-reflow had a poorer left ventricular ejection fraction and a higher prevalence of diabetes compared to the group with normal coronary flow. Individuals with a lower grade of TIMI flow had a substantially higher TyG index (9.7±0.25 vs. 8.8±0.5, p=0.001). The receiver operating characteristic (ROC) curve revealed that the optimal cut-off point of the TyG index for predicting no-reflow was >9.2 with specificity of 72.8% and sensitivity of 97.5% (area under the curve = 0.884; 95% confidence interval, 0.837-0.921; p=0.001). Conclusion: At admission, patients with STEMI who experienced no reflow after primary PCI had a higher TyG index. In such cases, the TyG index can be utilized as a predictor of no-reflow.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

No-reflow phenomenon and triglyceride-glucose index in acute myocardial infarction

Kerkutluoglu,

Celik,

Dagli

et al. 2023

J CLIN MED KAZ

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“…У взрослых верхняя граница по данным зарубежной литературы составляет 8,8 [14]. По данным испанского исследования Gesteiro E., et al (2018), верхняя граница у новорожденных составляет 7,8 [15], а по результатам крупного иранского исследования точка отсечения у детей в возрасте от 7-18 лет -8,33 [16]. По нашим данным, индекс не выходил за рамки ориентировочно нормальных, но, тем не менее, необходимы крупномасштабные исследования на детской популяции с целью определения нормальных значений индекса в соответствии с возрастными периодами.…”

Section: обсуждение основного результата исследованияunclassified

The relationship of eating behavior with biochemical blood parameters in children and adolescents born preterm

et al. 2019

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BACKGROUND: Prematurity is a risk for the formation of adverse metabolic disorders, the components of which can progress and lead to obesity. However, at the moment, the presence and nature of interrelations of metabolic parameters with the type of nutrition have not been established, there is also no clear idea of the age and structure of the initial manifestations of metabolic shifts, the prevalence of eating disorders in children born prematurely. AIMS: To determine the frequency and structure of the initial manifestations of the metabolic syndrome (abdominal obesity, impaired glucose tolerance, dyslipidemia, hypertension); to establish associations of types of eating behavior with biochemical parameters characterizing the adverse metabolic phenotype in children and adolescents born prematurely. MATERIALS AND METHODS: The study involved 123 children: in the main group (group 1) there were children and adolescents aged 10-17 years 11 months who were born prematurely (less than 37 weeks at birth and less than 2500 grams at birth), in the control group (group 2) included full-term children (more than 37 weeks and more than 2500 grams at birth). The study included clinical anthropometry with measurement of body weight, height, waist circumference (WC) and hips (HC), followed by calculation of body mass index (BMI) and ratio of WC/HC, measurement of blood pressure (BP). Eating behavior (EB) was assessed using a modified validated Dutch Eating Behavior Questionnaire (DEBQ). RESULTS: WC equal to or above the 90th percentile were only in children from the main group (4 children (9.7%).There were not observed such parameters in the control group (=4.63, p=0.047). BP higher than the 95th percentile was observed mainly in children born prematurely: 19 children (46.3%) against one (3.3%) of the control group (=21.94, p 0.001). Eating disorders are often found in both groups (59 of 123 (47.9%)): the control group had 35 of 65 (53.8%) children against 24 of 58 (41.4%) of the main group (p0.05). CONCLUSIONS: The components of metabolic syndrome are registered more often in children born prematurely. Eating disorders are often found in both groups.

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“…Some studies have shown that it is associated with coronary artery spasm and contraction [4], atherosclerotic plaque embolization [5], and severe glucose metabolism disorders [6]. TyG index has been proved to be a novel marker of insulin resistance [7], and is also associated with coronary atherosclerosis [8], glucose and lipid metabolism disorders [9][10], and microvascular endothelial dysfunction [11]. The above factors are also important pathological mechanisms for the occurrence of "no re ow "phenomenon after PCI.…”

Section: Introductionmentioning

confidence: 99%

Serum Triglycerides Fasting Glycemic Product Index Predict No-Reflow Phenomenon in Patients with Actue Myocardial Infarction Undergoing Primary Coronary Intervention

Liao

Yang

et al. 2021

Preprint

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Objective: To investigate the value of serum triglyceride and fasting glycemic index in predicting no reflow in patients with acute myocardial infarction after percutaneous coronary intervention. Methods: A total of 1037 patients with acute myocardial infarction who received PCI in the Department of Cardiology of Shanghai General Hospital and Jiading Branch of Shanghai General Hospital from January 2016 to May 2021 were retrospectively selected. According to postoperative TIMI blood flow classification, all patients were divided into no reflow group (TIMI blood flow≤grade 2) (309 cases) and reflow group (TIMI blood flow = grade 3) (728 cases). Clinical data, laboratory indicators and surgical information were collected from the two groups of patients. Logistic univariate and multivariate regression were used to analyze the independent risk factors of no reflow in actue myocardial infarction patients after PCI. ROC curve was used to analyze the best cut-off point for TyG index to predict the occurrence of no reflow. Results: The TyG index of no reflow group was significantly higher than of reflow group (7.16±0.64 vs 6.63±0.38, P=0.001). Multivariate logistic regression analysis showed that TyG index(OR=1.484,95%Cl 1.203-1.831,P< 0.001);WMSI(OR=2.640,95%Cl1.036-4.722,P=0.039);CSI (OR=2.299,95%Cl1.117-4.767,P=0.022) was independent predictors of no reflow phenomenon in patients with acute myocardial infarction after PCI .The area under the ROC curve predicted by TyG index after PCI without reflow was 0.809,95%Cl(0.740-0.879),higher than CSI and WMSI.When the TyG index was 6.995, the sensitivity and specificity of Youden index were 82.4% and 70.3% respectively at the maximum.Conclusion: TyG index can be used as an indicator to predict the occurrence of no-reflow in patients with acute myocardial infarction after PCI, which is helpful for clinicians to select high-risk patients and take interventions timely, so as to reduce the risk of no-reflow in patients after PCI.

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The triglyceride-glucose index, an insulin resistance marker in newborns?

Abstract: • This is the first study where TyG has been assessed in neonates. • TyG appears to be a suitable and cheap tool for identifying insulin resistance at birth.

Cited by 10 publications

References 23 publications

No-reflow phenomenon and triglyceride-glucose index in acute myocardial infarction

No-reflow phenomenon and triglyceride-glucose index in acute myocardial infarction

The relationship of eating behavior with biochemical blood parameters in children and adolescents born preterm

Serum Triglycerides Fasting Glycemic Product Index Predict No-Reflow Phenomenon in Patients with Actue Myocardial Infarction Undergoing Primary Coronary Intervention

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