The triglyceride-glucose index and contrast-induced nephropathy in non-ST elevation myocardial infarction patients undergoing percutaneous coronary intervention

Abstract

The triglyceride glucose (TyG) index is an indicator of insulin resistance and associated with increased risk of diabetes mellitus and cardiovascular events. Our study investigates the correlation between TyG index and contrast induced nephropathy (CIN) in non-diabetic patients with non-ST elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI). 350 non-diabetic NSTEMI patients (183, 52.3% male) undergoing PCI were retrospectively enrolled. The enrolled cohort was divided into 2 groups based on the calculated TyG index, namely values < 8.65 or higher. CIN was defined as an increase in serum creatinine > 25% or 0.5 mg/dL from baseline in the first 48 to 72 hours after PCI. A total of 56 (16%) cases of CIN were diagnosed. In contrast to patients with lower TyG indexes, patients with higher TyG indexes (≥8.65) had a higher frequency of CIN, 9.5%. versus 20.8% respectively ( P .004). Patients with CIN also had higher TyG indexes (8.74 ± 0.12 vs 8.67 ± 0.11, P < .001). In addition, TyG index, age, and glomerular filtration rate were identified as independent risk factors for CIN in logistic regression model (OR: 2.5 CI: 1.3–4.6, P .006, OR: 1.0 CI: 1.0–1.1, P < .001, OR: 1.0 KI: 1.03–1.06, P .025). In the ROC analysis, the area under the curve predictive of CIN was 0.666 ( P < .001, 95% [CI] 0.58–0.75) with a cutoff value of 8.69 (sensitivity 71,4%, specificity 55.1%) TyG index. Higher TyG indexes are associated with an increased risk of CIN in non-diabetic patients with NSTEMI.

Hot spots and trends in PCI prognostic research: A bibliometric analysis with CiteSpace

“…The “metabolic comorbidity problem” can significantly affect the prognosis of PCI and is also a treatment difficulty, making it a research hotspot. [ 25 ] TCM provides a systematic diagnosis and treatment of coronary heart disease. In recent years, evidence-based medicine has been continuously developed, and research has shown that TCM and other factors can affect the prognosis of PCI.…”

Diagnostic efficacy of the triglyceride–glucose index in the prediction of contrast-induced nephropathy following percutaneous coronary intervention

“…In another study of 350 patients without diabetes who were undergoing PCI for acute coronary syndrome, Gursoy and Baydar observed that the incidence of CIN was significantly higher in those with high TyG indices (≥8.65) than in those with lower indices (<8.65) (14). Importantly, the predictive value of the TyG index for CIN appears to be present even after adjusting for potential confounders such as diabetes status (13,14). While promising, research on the TyG index and CIN risk remains limited.…”

“…Studies have suggested that the TyG index could serve as a predictive marker for cardiovascular risk such as coronary artery disease, heart attack, and stroke (9,10,12). In addition, some studies have explored the potential connection between the TyG index and nephropathy, particularly in diabetic nephropathy (13)(14)(15)(16)(17). A higher TyG index, indicative of insulin resistance, can contribute to inflammation, oxidative stress, and vascular dysfunction (9,15,18).…”

“…Emerging evidence suggests that the TyG index may predict the risk of CIN (13,14). For instance, Aktas et al found that the TyG index was an independent predictor of CIN in 272 patients without diabetes who were undergoing PCI for non-ST elevation myocardial infarction (13).…”

“…For instance, Aktas et al found that the TyG index was an independent predictor of CIN in 272 patients without diabetes who were undergoing PCI for non-ST elevation myocardial infarction (13). In another study of 350 patients without diabetes who were undergoing PCI for acute coronary syndrome, Gursoy and Baydar observed that the incidence of CIN was significantly higher in those with high TyG indices (≥8.65) than in those with lower indices (<8.65) (14). Importantly, the predictive value of the TyG index for CIN appears to be present even after adjusting for potential confounders such as diabetes status (13,14).…”