The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults

Abstract

Objective We aimed to investigate the association between triglyceride glucose index and cardiovascular disease (CVD) development in the Chinese middle-aged and elderly population using the China Health and Retirement Longitudinal Study dataset 2011–2018. Methods Basic characteristics of participants, including sociodemographic information, and health conditions, were acquired. Logistic regression analyses and restricted cubic spline regression analyses were conducted to investigate the association between the triglyceride glucose index and future CVD risks. Subgroup analyses were performed to evaluate potential interaction. Results Seven hundred fifty-three of 6114 (12.3%) participants have developed CVD in 2018 over an approximately 7-year follow-up. The logistic regression analysis exhibited that compared to the lowest triglyceride glucose index group, the multivariable OR for future CVD was 0.985 (95%CI 0.811–1.198) in the T2 triglyceride glucose index group and 1.288 (95%CI 1.068–1.555) in the T3 TyG index (P for trend 0.006). The restricted cubic spline regression analysis showed the nonlinear association between triglyceride glucose index and CVD incidence; the cut-off values were 8.07 and 8.57, respectively, after total adjustment. Gender, fast blood glucose, and triglycerides interacted with triglyceride glucose index and CVD except for BMI. Conclusion The triglyceride glucose index was nonlinearly related to the risk of future cardiovascular disease in the middle-aged and elderly Chinese population.

Association between the triglyceride-glucose index and the risk of cardiovascular disease in Kurdish adult: Result from RaNCD cohort study

“…Finally, IR may be a process that causes diabetes and hypertension (24), A high level of TyG index can act as a surrogate biomarker of IR and cause lipotoxicity in the cardiovascular system in addition to the harmful vascular remodeling caused by oxygenation and systemic in ammation. Together, these elements-along with dyslipidemia and hypertension-increase the risk of CVD (25). This provides strong support for the hypothesis that a high TyG index can be a reliable biomarker for the development of cardiovascular disease.…”

An innovative model for predicting coronary heart disease using TyG-index: A machine learning-based cohort study

“…Studies have shown that TyG-index plays a significant role in CHD incidence in women [31,32,34,35,43,47,48], while one study reported a greater role in men [6],and another found no gender differences [44]. In this study, the association was found in both genders but only subsisted in women after multivariable adjustment.…”

“…Regardless of improved prevention methods and treatment techniques [1,2], it is still the leading cause of morbidity and mortality worldwide, representing 32% of all deaths [3,4] and mortality worldwide, representing 32% of all deaths and an enormous weight to the national health finances [5,6].Thus, CHD risk assessment is a global public health priority.…”

Relationship between a novel non–insulin-based metabolic score for insulin resistance (METS‐IR) and coronary artery calcification

“…Second. As mentioned earlier, IR can disrupt glucose metabolism, leading to compensatory increases in β-cell insulin production and hyperinsulinemia, which in turn leads to diabetes and other metabolic diseases closely related to CVD and CAC [ 40 , 41 ]. For example, Won et al confirmed that IR, represented by the TyG index, is an independent predictor of CAC progression, especially in adults with less severe baseline CAC [ 42 ].…”