The Triglycerides and Glucose Index rather than HOMA-IR is more associated with Hypogonadism in Chinese men

Abstract

Previous studies have reported that insulin resistant and low testosterone are related. The triglyceride and glucose index (TyG) well mirrors insulin sensitivity. No study investigated the application of TyG in male hypogonadism. We aimed to explore whether TyG was associated with hypogonadism, and also evaluate the ability of TyG compared to HOMA-IR as a possible hypogonadism predictor. A total of 4299 male subjects were enrolled from 22 sites in East China. Hypogonadism was defined as total testosterone <11.3 nmol/L. 695 (16.2%) hypogonadal men had significantly higher TyG index. The prevalence of hypogonadism stepwise increased across increasing TyG quartiles (P < 0.01). TyG was negatively associated with sex hormones and hypogonadism after adjustment for age, current smoking status, hypertension and overweight/obesity (all P for trend <0.01). The full-adjusted odds ratio was 6.1 for the highest quartile compared with the lowest quartile of TyG (95% CI 4.51, 8.25, P < 0.001). On ROC curve analysis, a larger area under the curve was found for TyG (0.71, 95% CI 0.69,0.73) than for HOMA-IR (0.68, 95% CI 0.66,0.70). Thus, the TyG was significantly associated with a higher prevalence of hypogonadism in Chinese men. TyG had a better predictive power for hypogonadism than HOMA-IR.

The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

“…In Brazil, Vasques et al reported better performance using the TyG index than HOMA-IR to estimate IR in Brazilian subjects [ 29 ]. Compared with HOMA-IR, several studies indicated that the TyG index was also superior at predicting carotid atherosclerosis, arterial stiffness, diabetes, and hypogonadism [ 15 , 30 – 32 ]. Similarly, this study found that the TyG index was more closely tied to NAFLD and liver steatosis than HOMA-IR.…”

Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR

“…The results are significantly associated with the "gold standard", the glucose clamp results (4). The standard of insulin resistance index (HOMA-IR) was different in every race, every country (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) .…”

Metabolic patterns in insulin-sensitive male hypogonadism

“…For these reasons, we performed two parallel investigations, in normoinsulinaemic hypogonadic males and hyperinsulinaemic subjects. The two groups were selected by homeostasis model assessment of IR-index (HOMAi), the most common index to assess insulin sensitivity 14 .…”