The Trilogy of SARS-CoV-2 in Pediatrics (Part 1): Acute COVID-19 in Special Populations

Parsons, Sarah; Tran, Van L

doi:10.5863/1551-6776-26.3.220

Cited by 4 publications

(5 citation statements)

References 64 publications

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“…It should be noticed that the increase in the frequency of severe cases was also associated with an increase of patients with concomitant pathology. As it is known from the previous studies, chronic pathology is one of the risk factors for severe and complicated course of COVID-19 in children [ 24 ]. Numerous meta-analyses indicate a progressive increase in the number of hospitalizations among children with concomitant background pathology during recent outbreaks, comparing to the beginning of the epidemic [ 25–27 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical course of COVID-19 in hospitalized children of Ukraine in different pandemic periods

Seriakova

Yevtushenko

Kramarov

et al. 2022

European Clinical Respiratory Journal

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Background The coronavirus infection (COVID-19) pandemic has seen a progressive increase in childhood morbidity worldwide. Continuous mutation of the SARS-CoV-2 virus causes the wave-like course of the COVID-19 pandemic, which is characterized by an undulating course and the predominance of different variants of the SARS-CoV-2 virus. There are many reports that the clinical picture may vary depending on the circulating strain of the virus [7–11, 13–16]. Based on this, we decided to analyze and evaluate the presence of a pattern between the clinical and epidemic COVID-19 characteristics and the strain of the SARS-CoV-2 virus prevailing locally. The aim of the work To study the effects of various strains of SARS-CoV-2 on the clinical and epidemiological characteristics of pediatric patients; to determine the regularity between the severity of the disease and the circulating strain of SARS-CoV-2. Materials and methods A retrospective analysis of 945 case stories of COVID-19 disease in children who were hospitalized at the infectious diseases hospital (Kyiv, Ukraine) in the period from June 2020 to February 2022 (corresponding to a period of four waves of different SARS-CoV-2 strains). We investigated epidemiological and clinical features, as well as laboratory and instrumental parameters, comparing four waves of the disease. Results and Conclusions A regularity between the wave of COVID-19 and the severity of the disease was found. The third wave seemed to be the most severe, due to the increase in the frequency of complications, concomitant pathology, clinical symptoms and the level of mortality. The timing of this outbreak matched with the circulation of the SARS-CoV-2 delta-variant and correlated with an increase in hospitalization rates in Ukraine.

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Section: Discussionmentioning

confidence: 99%

Clinical course of COVID-19 in hospitalized children of Ukraine in different pandemic periods

Seriakova

Yevtushenko

Kramarov

et al. 2022

European Clinical Respiratory Journal

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“…The SARS-CoV-2, an enveloped RNA virus, is predominantly transmitted via respiratory droplets [ 2 ]. After contact with the virus, it enters the human cells via the angiotensin-converting enzyme 2 (ACE2) receptor using its spike protein S1 subunit.…”

Section: Introductionmentioning

confidence: 99%

“…While primarily expressed in the lungs, the ACE2 receptor is also expressed in many extrapulmonary tissues, including the gastrointestinal (GI) tract. High levels of ACE2 receptors were found on the luminal surface of differentiated epithelial cells in the terminal ileum and colon [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Acute COVID-19 infections in pediatric patients have been milder in severity, with quicker recovery and fewer sequelae compared to adult infection [ 4 , 5 ]. This difference is believed to be due to multiple factors such as variations in the distribution of ACE2 receptors, T-cell and B-cell responses, and the balance of modulating and proinflammatory cytokines [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of COVID-19 in Pediatric Patients and Young Adults with Inflammatory Bowel Disease

Magalhães

Granado²,

Manuel

et al. 2022

GE Port J Gastroenterol

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Introduction: Acute COVID-19 in pediatric and young adult patients tends to be milder in severity compared to adult infection. Recent studies seem to show that inflammatory bowel disease (IBD) patients are at no greater risk than the general population. We aim to describe our experience in the follow-up of pediatric and young adult patients with IBD followed in our center and determine possible risk factors of said population for severe COVID-19. Methods: We performed a retrospective study of all patients aged under 25 years followed for IBD at the Unit of Pediatric Gastroenterology in a tertiary center between December 2019 and April 2021 evaluating the incidence of COVID-19 and characterization of positive cases. Results: Of the 268 participants, 24 had COVID-19: the mean age was 19 years old and gender had an equal distribution; 75% (n = 18) had Crohn’s disease, whereas only 25% (n = 6) had ulcerative colitis. Most patients were in clinical remission (n = 21). The majority of patients were under treatment with a tumor necrosis factor (TNF) antagonist (58%, n = 14), mainly infliximab, and most had no comorbidities other than IBD (83%). Regarding COVID-19, 17% of the patients were asymptomatic while the rest had only mild symptoms. There were no reported gastrointestinal complaints, no complications nor hospitalizations. Most patients did not require interruption of their IBD treatment. Conclusions: Our data suggest that pediatric and young adult IBD patients have a low risk for complications and hospitalization, regardless of IBD treatment. We believe that this experience is encouraging and allows for safe counseling regarding treatment options and school attendance in pediatric and young adult IBD patients.

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“…The COVID SARS-CoV-2, is an enveloped RNA virus, that first originated in Wuhan, China, and since then it has spread to over 213 countries and regions. On the 11th of March, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic [1]. And, as of the 17th of April 2020, there have been 1,995,983 cases and 131,037 deaths [2].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Adverse Reactions to Different COVID-19 Vaccinations among Karachi Residents

Malik

Faraz

Bhatty

et al. 2021

JPRI

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Background: Coronavirus disease 2019 (COVID-19) pandemic emerged in Karachi and rapidly spread throughout Pakistan Since February 26, 2020. Objectives: Vaccination is currently one of the most effective COVID-19 eradication approach. The purpose of this study was to gather data on the adverse effects of the COVID-19 vaccine. Methodology: It was an observational study that was carried out between the 11th and 23rd of April 2021, and the participants were Karachi residents. We looked at the proportion of self-reported local and systemic adverse effects within seven days of immunization in people who filled out Google forms and received one or two doses of the vaccine. Results: The vaccination ratio for male was slight higher than females. Participants aged between 51 to 60 years and 41 to 50 years had higher number of vaccinations. Sinopharm is by far the most widely used vaccine. After the first dose of vaccination, the majority of participants complained of fever, chills, muscle pain, and arm pain, whereas after the second dose, the majority of participants had no symptoms, with a few participants complaining of fever, chills, diarrhea, and muscle pain. Conclusion: The first and second doses' post-vaccination adverse effects were mild and predictable, and there were no hospitalizations; this data can help lessen vaccine hesitancy.

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The Trilogy of SARS-CoV-2 in Pediatrics (Part 1): Acute COVID-19 in Special Populations

Cited by 4 publications

References 64 publications

Clinical course of COVID-19 in hospitalized children of Ukraine in different pandemic periods

Clinical course of COVID-19 in hospitalized children of Ukraine in different pandemic periods

Impact of COVID-19 in Pediatric Patients and Young Adults with Inflammatory Bowel Disease

Prevalence of Adverse Reactions to Different COVID-19 Vaccinations among Karachi Residents

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