The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates

Ozkan, Erva; Bakar‐Ates, Filiz

doi:10.2174/1871523018666191023141807

Cited by 15 publications

(8 citation statements)

References 141 publications

(144 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequent functional enrichment analysis of these four modules unveiled connections to pathways related to esophageal cancer progression, multiple research studies corroborate with these findings. Specifically, Module 1 has shown significant connections to translational elongation and ribosomal functions ( Figure 4A ; Temaj et al, 2022 ), Module 2 is linked to histone function, activation of matrix metalloproteinases, and interferon signaling ( Figure 4B ; Jiao et al, 2014 ; Mittal et al, 2016 ; Ozkan and Bakar-Ates, 2020 ), Module 3 is primarily associated with mRNA regulation ( Figure 4C ; Teng et al, 2022 ), and Module 4 is chiefly related to chemokine activity ( Figure 4D ; Nicolau-Neto et al, 2018 ). Each of these modules seems to have a unique role in the progression of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan

Sharip,

Rakhimova,

Molkenov

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer in Central Asia, often diagnosed at advanced stages. Understanding population-specific patterns of ESCC is crucial for tailored treatments. This study aimed to unravel ESCC’s genetic basis in Kazakhstani patients and identify potential biomarkers for early diagnosis and targeted therapies. ESCC patients from Kazakhstan were studied. We analyzed histological subtypes and conducted in-depth transcriptome sequencing. Differential gene expression analysis was performed, and significantly dysregulated pathways were identified using KEGG pathway analysis (p-value < 0.05). Protein-protein interaction networks were constructed to elucidate key modules and their functions. Among Kazakhstani patients, ESCC with moderate dysplasia was the most prevalent subtype. We identified 42 significantly upregulated and two significantly downregulated KEGG pathways, highlighting molecular mechanisms driving ESCC pathogenesis. Immune-related pathways, such as viral protein interaction with cytokines, rheumatoid arthritis, and oxidative phosphorylation, were elevated, suggesting immune system involvement. Conversely, downregulated pathways were associated with extracellular matrix degradation, crucial in cancer invasion and metastasis. Protein-protein interaction network analysis revealed four distinct modules with specific functions, implicating pathways in esophageal cancer development. High-throughput transcriptome sequencing elucidated critical molecular pathways underlying esophageal carcinogenesis in Kazakhstani patients. Insights into dysregulated pathways offer potential for early diagnosis and precision treatment strategies for ESCC. Understanding population-specific patterns is essential for personalized approaches to ESCC management.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan

Sharip,

Rakhimova,

Molkenov

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Extracellular matrix (ECM) is a complex macromolecule network which is composed of fibers, proteoglycans, glycoproteins and polysaccharides [ 28 ], and plays a critical pole in the cell morphology, functions, migration, proliferation, differentiation and survival through signaling pathways. Matrix metalloproteinases (MMPs), proteolytic enzymes of the ECM, are a zinc-dependent endopeptidase family mainly responsible for tissue remodeling in various physiological and pathological processes [ 29 ]. MMPs could degrade ECM proteins and glycoproteins, membrane receptors, cytokines, and growth factors.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Ameliorates Lipopolysaccharide-Induced Duodenal Inflammation through Modulating Autophagy, Programmed Cell Death and Intestinal Mucosal Barrier Function in Chicken Embryos

Cao

et al. 2022

Animals

View full text Add to dashboard Cite

Diarrhea has been a global health problem for centuries, and the treatment has become increasingly difficult duo to the antibiotics overuse and resistance. Quercetin is a common flavonoid of extracts of vegetables, fruits, and traditional Chinese herbs, however, the mechanism of quercetin alleviating LPS-induced duodenal inflammation remains elusive. Specific pathogen-free chicken embryos (n = 120) were allocated to groups including control, PBS with or without alcohol, LPS (125 ng/egg) with or without quercetin (10, 20, or 40 nmol/egg, respectively), and quercetin groups (10, 20, or 40 nmol/egg). Fifteen day-old embryonated eggs were inoculated with abovementioned solutions via the allantoic cavity. At embryonic day 19, the duodena of the embryos were collected for histopathological examination, RNA extraction and real-time polymerase chain reaction, immunohistochemical investigations, and Western blotting. The results demonstrated quercetin enhanced the inflammatory cell infiltration in the Peyer’s patch of the intestinal mucosa after LPS induction. The LPS-induced expressions of these inflammation-related factors (TLR4, IL-1β, MMP3, MMP9, NFKB1, IFNγ, IL-8, IL-6) were completely blocked by quercetin. Quercetin also decreased the protein expression of TLR4, IL-1β, MMP3, and MMP9 after LPS induction. Quercetin could down-regulate autophagy gene expression (ATG5, LC3-1, LC3-2, and LKB1), and decreased the protein expression of ATG5, and LC3-1/LC3-2 after LPS induction. Quercetin treatment prevented LPS-induced increases of the gene expressions of programmed cell death factors (TNFα, Fas, CASP1, CASP3, CASP12, Drp1, and RIPK1); meanwhile, quercetin decreased the protein expression of CASP1 and CASP3 after LPS challenge. LPS reduced the gene expression of mucin 2, but upregulated the mRNA and protein expression of claudin 1, occludin, and ZO-1, and this was balanced by quercetin. This evidence suggests that quercetin can alleviate duodenal inflammation induced by LPS through modulating autophagy, programmed cell death, intestinal barrier function.

show abstract

“…Key approaches include the use of MMP inhibitors, anti-inflammatory agents, such as corticosteroids and cytokine inhibitors (e.g. IL-6 inhibitor), and growth factors (TGF-β, vascular endothelial growth factor, and epidermal growth factor) that promote cell proliferation and repair of damaged lung tissues, which is essential for maintaining ECM integrity and restoring lung function [ 124 ].…”

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Al-Husinat,

Azzam,

Al Sharie

et al. 2024

Crit Care

View full text Add to dashboard Cite

Background Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in conditions such as acute respiratory distress syndrome (ARDS). This review discusses the detailed structure of the ECM in healthy and ARDS-affected lungs under mechanical ventilation, aiming to bridge the gap between experimental insights and clinical practice by offering a thorough understanding of lung ECM organization and the dynamics of its alteration during mechanical ventilation. Main text Focusing on the clinical implications, we explore the potential of precise interventions targeting the ECM and cellular signaling pathways to mitigate lung damage, reduce inflammation, and ultimately improve outcomes for critically ill patients. By analyzing a range of experimental studies and clinical papers, particular attention is paid to the roles of matrix metalloproteinases (MMPs), integrins, and other molecules in ECM damage and VILI. This synthesis not only sheds light on the structural changes induced by mechanical stress but also underscores the importance of cellular responses such as inflammation, fibrosis, and excessive activation of MMPs. Conclusions This review emphasizes the significance of mechanical cues transduced by integrins and their impact on cellular behavior during ventilation, offering insights into the complex interactions between mechanical ventilation, ECM damage, and cellular signaling. By understanding these mechanisms, healthcare professionals in critical care can anticipate the consequences of mechanical ventilation and use targeted strategies to prevent or minimize ECM damage, ultimately leading to better patient management and outcomes in critical care settings.

show abstract

The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates

Cited by 15 publications

References 141 publications

Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan

Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan

Quercetin Ameliorates Lipopolysaccharide-Induced Duodenal Inflammation through Modulating Autophagy, Programmed Cell Death and Intestinal Mucosal Barrier Function in Chicken Embryos

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Contact Info

Product

Resources

About