The Triple Crown: NO, CO, and H2S in cancer cell biology

Oza, Palak P.; Kashfi, Khosrow

doi:10.1016/j.pharmthera.2023.108502

Cited by 11 publications

(3 citation statements)

References 530 publications

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“…However, gasotransmitters do not act individually in the body; they are usually implemented in physiological processes on either a synergistic or antagonistic role through subtle interactions among them. 48 By availing of the reversibility of DGBs, one could design gas-releasing materials that release multiple gases in either synergistic or cascading mode (Figure 8, right panel), which provides an enhanced or diminished effect for biomedical applications, such as gas therapeutics.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Gas-Bridged Bond: An Opportunity of Fabricating Dynamic Assembled Materials with Gas

Yang,

Wang,

Yan

2024

ACS Appl. Mater. Interfaces

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Gas molecules, as a family of unique polyatomic building blocks, have long been considered hard to involve in molecular assembly or construct assembled materials due to their structural simplicity yet paucity of defined interacting sites. To solve this non-trivial challenge, a core idea is to break the limit of current ways of bonding gas molecules, endowing them with new modes of interactions that match the basic requirements of molecular assembly. In recent years, a new concept, named the dynamic gas-bridged bond (DGB), has emerged, which allows for gas molecules to constitute a dynamic bridging structure between other building blocks with the aid of frustrated Lewis pairs. This makes it possible to harness gas in a supramolecular or dynamic manner. Herein, this perspective discusses distinct dynamic natures of DGBs and manifests their particular functions in various fields, including the control of molecular/polymeric self-assembly nanostructures, creation of multidimensional assembled materials, and recyclable catalysts. The future research direction and challenges of dynamic gas-bridged chemistry toward gas-programmed self-assembly and gas-constructed adaptive materials are highlighted.

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Section: Discussionmentioning

confidence: 99%

Dynamic Gas-Bridged Bond: An Opportunity of Fabricating Dynamic Assembled Materials with Gas

Yang,

Wang,

Yan

2024

ACS Appl. Mater. Interfaces

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“…Hydrogen sulfide (H2S) is an endogenously produced gas with known antioxidant and neuroprotective properties. H2S has a complex interaction with NO, which can upregulate eNOS expression, increase NO bioavailability by reducing oxidative stress, and enhance downstream NO signaling by inhibiting PDE5A activity [80]. Like NO, enhanced H2S production has been proposed as a universal response to hypoxic stress.…”

Section: Potential Mechanisms Regulating Renin Under Hypoxiamentioning

confidence: 99%

Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review

Kong,

Liao,

Zhao

et al. 2023

Biomedicines

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The renin–angiotensin system (RAS) and hypoxia have a complex interaction: RAS is activated under hypoxia and activated RAS aggravates hypoxia in reverse. Renin is an aspartyl protease that catalyzes the first step of RAS and tightly regulates RAS activation. Here, we outline kidney renin expression and release under hypoxia and discuss the putative mechanisms involved. It is important that renin generally increases in response to acute hypoxemic hypoxia and intermittent hypoxemic hypoxia, but not under chronic hypoxemic hypoxia. The increase in renin activity can also be observed in anemic hypoxia and carbon monoxide-induced histotoxic hypoxia. The increased renin is contributed to by juxtaglomerular cells and the recruitment of renin lineage cells. Potential mechanisms regulating hypoxic renin expression involve hypoxia-inducible factor signaling, natriuretic peptides, nitric oxide, and Notch signaling-induced renin transcription.

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“…NO binding to sGC induces an increase in cGMP formation, thereby amplifying the initial NO signal through a series of processes that further activate cGMP-dependent protein kinases, ion channels, and phosphodiesterases [ 15 , 16 ]. Therefore, the dysregulation of the NO-sGC-cGMP signaling pathway is associated with a variety of diseases, such as cancer and hypertension as well as cardiovascular and neurodegenerative diseases [ 17 , 18 , 19 , 20 ]. On the other hand, NO scavenging by various heme proteins, including hemoglobin (Hb) and myoglobin (Mb), can have contrasting effects by inducing vasoconstriction [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction

De Simone,

di Masi,

Sbardella

et al. 2024

Antioxidants

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Nitric oxide (NO) synthesis, signaling, and scavenging is associated to relevant physiological and pathological events. In all tissues and organs, NO levels and related functions are regulated at different levels, with heme proteins playing pivotal roles. Here, we focus on the structural changes related to the different binding modes of NO to heme-Fe(II), as well as the modulatory effects of this diatomic messenger on heme-protein functions. Specifically, the ability of heme proteins to bind NO at either the distal or proximal side of the heme and the transient interchanging of the binding site is reported. This sheds light on the regulation of O2 supply to tissues with high metabolic activity, such as the retina, where a precise regulation of blood flow is necessary to meet the demand of nutrients.

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The Triple Crown: NO, CO, and H2S in cancer cell biology

Cited by 11 publications

References 530 publications

Dynamic Gas-Bridged Bond: An Opportunity of Fabricating Dynamic Assembled Materials with Gas

Dynamic Gas-Bridged Bond: An Opportunity of Fabricating Dynamic Assembled Materials with Gas

Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review

Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction

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