The Troponins

Coudrey, Laura

doi:10.1001/archinte.158.11.1173

Cited by 78 publications

(54 citation statements)

References 58 publications

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“…10,11 Troponins are proteins found in cardiac and skeletal muscle, and the troponin complex (subunits I, T, and C) on the thin filament regulates the force and velocity of muscle contractions. Cardiac troponin T (TnT) is a specific and highly sensitive marker of myocardial injury and degeneration, 12 and the diagnostic and prognostic value of this marker has been established and extensively reported for acute coronary syndromes. 13,14 Furthermore, its significance in DCM 15 and ADR-CM [16][17][18] has been recently reported.…”

mentioning

confidence: 99%

Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats

Koh

Nakamura

Takahashi

2004

Circ J

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confidence: 99%

Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats

Koh

Nakamura

Takahashi

2004

Circ J

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“…The diagnostic and prognostic value of this marker has been established and extensively reported in acute coronary syndromes. [2][3][4] However, its significance in DCM is not known. Microscopic abnormalities associated with DCM are roughly divided between myocytic degeneration and interstitial changes.…”

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confidence: 99%

Persistently Increased Serum Concentrations of Cardiac Troponin T in Patients With Idiopathic Dilated Cardiomyopathy Are Predictive of Adverse Outcomes

et al. 2001

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Background-The measurement of serum concentrations of cardiac troponin T (TnT) is a simple, useful method to detect myocyte injury that may be repeated multiple times to follow patients without interobserver variability. Methods and Results-Multiple measurements of TnT with a second-generation assay were performed in 60 patients with dilated cardiomyopathy confirmed by coronary angiography and endomyocardial biopsy between April 1996 and December 1999. Three evolutionary patterns of TnT concentrations were identified. Thirty-three patients had concentrations of TnT Ͻ0.02 ng/mL throughout the follow-up period (group 1). The remaining 27 patients had high initial serum concentrations of TnT (Ն0.02 ng/mL). In 10 of these 27 patients, TnT decreased to Ͻ0.02 ng/mL during follow-up (group 2), whereas 17 had persistently high serum TnT concentrations despite being conventionally treated for chronic congestive heart failure (group 3). Although the initial echocardiographic left ventricular diastolic dimension (LVDd) and left ventricular ejection fraction (LVEF) were not significantly different among the 3 groups, follow-up echocardiography showed significantly decreased LVDd and increased LVEF in group 1 (each PϽ0.01) and group 2 (each PϽ0.05) compared with increased LVDd and decreased LVEF in group 3 (each PϽ0.05). The cardiac event-free rate was significantly lower in group 3 than in groups 1 and 2 (each PϽ0.001), and the survival rate was lower in group 3 than in group 1 (PϽ0.05). Conclusions-Persistently increased

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“…Binding of endotoxins to cellular membrane receptors initiate inflammation and cytokines procuction, which lead to hepatic dysfunction and increase in AST activity. The MB isoenzyme of creatine kinase is normally present in the skeletal muscle in low amounts and substantial injury to skeletal muscle can increase CK-MB activity and significally elevate values to abnormal levels (Coudrey, 1998). This is an important consideration in ARLA, in which liver impairment and secondary rhabdomyolysis due to recumbency can occur.…”

Section: Resultsmentioning

confidence: 99%

“…Several biomarkers have been used for the detection of myocardial injury including cardiac troponins, lactate dehydrogenase (LDH), creatine kinase (CK), MB isoenzyme of CK (CK-MB), along with electrocardiogram (ECG), but measurement of serum troponins has been shown to be more specific and sensitive than others (Coudrey et al, 1998;Babuin and Jaffe, 2005;Collinson and Gaze, 2007). Cardiac troponin I (cTnI) is a more sensitive and persistent indicator of cardiac injury, with high tissue specificity, than other markers in the presence of marked skeletal muscle injury, liver disease, and chronic renal failure (O'Brien et al, 1997;Adin et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Fartashvand

Hajisadeghi

2018

J Hellenic Vet Med Soc

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In this study we investigated the changes of cardiac injury biomarkers in serum samples from 200 sheep with acute ruminal lactic acidosis (ARLA) and 50 healthy controls belonging to the Ghezel breed. After clinical examination and recording of vital signs (heart rate, respiratory rate, rectal temperature and hydration status), rumen fluid and venous blood samples were collected. The pH of rumen fluid was determined using a paper tape pH-meter and lactic acid concentration of serum was measured using a commercially available method. Similarly, activities of AST, LDH, CK-MB and serum concentration of cTnI were measured using special commercial kits. According to the findings serum activities of AST (p = 0.007) and CK-MB (p = 0.002) in sheep with ARLA were significantly higher than in healthy animals. Serum LDH activity in the disease group was higher than in the control group, however this difference was statistically non-significant. cTnI concentration were 0.684 ± 0.03 ng/ml in sheep with ARLA, which was significantly higher than in healthy sheep (p = 0.000). There were significant negative correlations between ruminal pH and serum lactate levels, heart rate, respiratory rate and dehydration degree. The sheep with the lowest ruminal pH (3 cases with < 4.5) had the highest levels of cTnI (2.28 to 3.06 ng/mL), and all died. It can be concluded that lactic acidosis may cause some degree of heart damage, although further studies are needed to support this speculation.

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The Troponins

Cited by 78 publications

References 58 publications

Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats

Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats

Persistently Increased Serum Concentrations of Cardiac Troponin T in Patients With Idiopathic Dilated Cardiomyopathy Are Predictive of Adverse Outcomes

Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

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