The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic <i>Lactobacillus reuteri</i> DSM 17938

Perez-Burgos, Azucena; Wang, Lu; Neufeld, Karen‐Anne McVey; Mao, Yu; Ahmadzai, Mustafa; Janssen, Luke J.; Stanisz, Andrew M.; Bienenstock, John; Kunze, Wolfgang

doi:10.1113/jp270229

Cited by 109 publications

(83 citation statements)

References 76 publications

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“…Lastly, Perez‐Burgos et al . () have reported that the administration of L. johnsonii to jejunum had reduced the firing rate of vagal afferent fibres in ex vivo jejunal segment mesenteric nerve recording preparation. It is assumed that changing the firing rate of VN can induce secretions of serotonin, GABA, and glutamate in the brain, but since there is no an in vivo study, it is still hypothetical.…”

Section: The Modification Of Vagal Afferent Fibresmentioning

confidence: 97%

The role of gut microbiota in pathogenesis of Alzheimer's disease

Bostancıklıoğlu

2019

Journal of Applied Microbiology

151

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This paper describes the effects of the gut microbiota on the pathogenesis of Alzheimer's pathology by evaluating the current original key findings and identifying gaps in the knowledge required for validation. The diversity of the gut microbiota declines in the elderly and in patients with Alzheimer's disease (AD). Restoring the diversity with probiotic treatment alleviates the psychiatric and histopathological findings. This presents a problem: How does gut microbiota interact with the pathogenesis of AD? The starting point of this comprehensive review is addressing the role of bacterial metabolites and neurotransmitters in the brain under various conditions, ranging from a healthy state to ageing and disease. In the light of current literature, we describe three different linkages between the present gut microbiome hypothesis and the other major theories for the pathogenesis of AD as follows: bacterial metabolites and amyloids can trigger central nervous system inflammation and cerebrovascular degeneration; impaired gut microbiome flora inhibits the autophagy‐mediated protein clearance process; and gut microbiomes can change the neurotransmitter levels in the brain through the vagal afferent fibres.

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Section: The Modification Of Vagal Afferent Fibresmentioning

confidence: 97%

The role of gut microbiota in pathogenesis of Alzheimer's disease

Bostancıklıoğlu

2019

Journal of Applied Microbiology

151

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“…[69] Bacterial modulation of spinal cord responses has been demonstrated using probiotic species; the presence of live Lactobacillus reuteri reduces spinal nerve firing in response to the introduction of painful visceral stimulation. [70] …”

Section: Spinal Cord Transmission Of Microbiota To Amygdala Signalsmentioning

confidence: 99%

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

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The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18

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“…We have been extensively involved in studies of the effects of the gut microbiota on the functions of the enteric nervous system and brain including behaviour (Bienenstock et al ., ; Perez‐Burgos et al ., ; Forsythe et al ., ). This field has become known as the gut–brain axis or the microbiota–gut–brain axis.…”

Section: General Commentarymentioning

confidence: 98%

Disruptive physiology: olfaction and the microbiome–gut–brain axis

2017

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This review covers the field of olfaction and chemosensation of odorants and puts this information into the context of interactions between microbes and behaviour; the microbiome-gut-brain axis (MGBA). Recent emphasis has also been placed on the concept of the holobiome which states that no single aspect of an organism should be viewed separately and thus must include examination of their associated microbial populations and their influence. While it is known that the microbiome may be involved in the modulation of animal behaviour, there has been little systematized effort to incorporate into such studies the rapidly developing knowledge of the wide range of olfactory systems. The classical olfactory system is evolutionarily conserved in multiple taxa from insects through to fish, reptiles and mammals, and is represented by the largest gene families in vertebrates. Mice have over 1000 different olfactory receptors and humans about 400. They are distributed throughout the body and are even found in spermatozoa where they function in chemotaxis. Each olfactory receptor has the unique functional capability of high-affinity binding to several different molecular ligands. These and other properties render the cataloguing of odorants (odorome) with specific actions a difficult task. Some ectopic olfactory receptors have been shown to have functional effects in the gut and kidney, highlighting the complexity of the systems engaged by odorants. However, there are, in addition to classical olfactory receptors, at least two other families of receptors involved in olfaction that are also widely found expressed on tissues in many different organs in addition to the nervous system and brain: the trace-amine associated and formyl peptide receptors. Bacteria can make many if not most odorants and are responsible for recognition of species and relative relatedness, as well as predator presence, among many other examples. Activation of different combinations of olfactory receptors by bacterial products such as β-phenylethylamine have been shown even to control expression of emotions such as fear and aggression. The number of examples of bacterial products and volatile odorants influencing brain function and behaviour is expanding rapidly. Since it is recognized that many different bacterial products and metabolites also function as social cues, and may themselves be directly or indirectly causative of behavioural change, it becomes ever more important to include olfaction into studies of the MGBA. Clearly there are broader implications for the involvement of olfaction in this rapidly evolving field. These include improvement in our understanding of the pathways engaged in various behaviours, and the identification of novel approaches and new targets in efforts to modulate behavioural changes.

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The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938

Cited by 109 publications

References 76 publications

The role of gut microbiota in pathogenesis of Alzheimer's disease

The role of gut microbiota in pathogenesis of Alzheimer's disease

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Disruptive physiology: olfaction and the microbiome–gut–brain axis

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